Peripheral biomarkers of endometriosis: a systematic review

Kevin May; K E May; S A Conduit-Hulbert; José Villar; J Villar; S Kirtley; Shona Kirtley; S H Kennedy; Sidney H. Kennedy; Christian M. Becker; C M Becker

doi:10.1093/humupd/dmq009

Peripheral biomarkers of endometriosis: a systematic review

Kevin May, K E May, S A Conduit-Hulbert, José Villar, J Villar, S Kirtley, Shona Kirtley, S H Kennedy, Sidney H. Kennedy, Christian M. Becker, C M Becker

Human reproduction update · 2010 · vol. 16(6) , pp. 651–674 · doi:10.1093/humupd/dmq009 · PMID:20462942 · PMC2953938 · W2160282642

review OA: green CC0 ⤵ 324 in-corpus citations

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This systematic review of over 100 peripheral biomarkers for endometriosis found no single marker or panel definitively proven useful for clinical diagnosis or monitoring.

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Abstract

BACKGROUND: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage. METHODS: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine. RESULTS: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful. CONCLUSIONS: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Antibodies Antibodies Antibodies Antibodies Apoptosis Biomarkers Biomarkers Biomarkers Cell Adhesion Cytokines Cytokines Cytokines Cytokines Endometriosis Endometriosis Endometriosis Female Glycoproteins

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References (100)

Cited by (50)

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