Autoantibodies associated with endometriosis: Can their detection predict presence of the disease?
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This study evaluated an indirect immunofluorescence assay for detecting autoantibodies in sera, finding 83% sensitivity and 65-76% specificity for diagnosing endometriosis.
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Abstract
To evaluate the usefulness of autoantibody detection as a nonoperative method of diagnosing endometriosis, we tested 221 sera from 215 patients from the infertility, gynecology, and gynecologic oncology services by an indirect immunofluorescence assay using monolayer cultures of an endometrial carcinoma cell line. The assay showed positive cytoplasmic staining, demonstrating a sensitivity of 83% in the patients with laparoscopically confirmed endometriosis. The specificity of the assay was 65% for the infertility patients and 76% for the infertility and gynecology patients combined. Several gynecologic cancer patients showed either nuclear or nuclear and cytoplasmic staining, but few showed exclusive cytoplasmic staining. These initial results suggest that detection of antibodies might be useful for the diagnosis of endometriosis.
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Cited by (26)
- Increased risk of rheumatoid arthritis in patients with endometriosis: genetic aspects 2022
- Endometriosis and autoimmunity: Can autoantibodies be used as a non-invasive early diagnostic tool? 2021
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Endometriosis and Immunology 2013
- Endometriosis and Autoimmunity 2011
- Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies 2011
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Biomarkers of endometriosis 2008
- Multiple endometrial antigens are targeted in autoimmune endometriosis 2008
- Targeting Mast Cells in Endometriosis with Janus Kinase 3 Inhibitor, JANEX‐1 2007
- Serum Antiendometrial Antibodies and Diagnosis of Endometriosis 2007
- Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls 2006
- Peritoneal fluid environment in endometriosis. Clinicopathological implications. 2003
- Peritoneal fluid environment in endometriosis 2003
- Immunology of endometriosis 2002
- Immunobiology of endometriosis 2001
- 10.1016/s1047-9422(03)00073-7 2000
- Immunology of endometriosis 1999
- A preliminary immunopharmacological study of an antiendometriotic herbal medicine, Keishi-bukuryo-gan. 1998
- Autoantibodies and infertility: a review of the literature 1997
- Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis. 1996
- Anti-endometrial antibodies in women measured by an enzyme-linked immunosorbent assay 1996
- Diseases of the Peritoneum 1994
- Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis 1993
- 4 Markers for endometriosis 1993
- In vitro lymphocyte activity in women with endometriosis—an altered immune response? 1992
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