Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis

Khorram O, Omid Khorram, O Khorram, Robert N. Taylor, Taylor RN, R N Taylor, I. P. Ryan, Ryan IP, Isabelle P. Ryan, T J Schall, Schall TJ, Thomas J. Schall, D V Landers, Landers DV
American journal of obstetrics and gynecology · 1993 · vol. 169(6) , pp. 1545–1549 · doi:10.1016/0002-9378(93)90433-j · PMID:7505529 · W2109748444
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This study found that higher concentrations of the cytokine RANTES in peritoneal fluid are associated with more severe stages of endometriosis.

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Abstract

ObjectiveEndometriosis is a common gynecologic disorder in which the concentration and activation of peritoneal macrophages are increased. The goal of this study was to quantify pelvic fluid concentrations of two cytokines involved in macrophage recruitment and activation.Study designA case-control study of women undergoing pelvic surgery was conducted by collecting peritoneal fluid from 12 women without evidence of endometriosis (controls), 12 with mild, and 12 with moderate to severe endometriosis. Concentrations of RANTES and interferon gamma, soluble cytokines known to recruit and activate macrophages, were quantified by enzyme-linked immunosorbent assays.ResultsPelvic fluid concentrations of RANTES are elevated in women with endometriosis and the levels correlate with the severity of disease. By contrast, concentrations of interferon gamma appear unaffected by the presence of or severity of endometriosis.ConclusionThe findings indicate that RANTES, a cytokine with potent chemotactic activity for human monocytes, may play an important role in the recruitment of peritoneal macrophages in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Lymphokines Adult Ascitic Fluid Case-Control Studies Chemokine CCL5 Cytokines Endometriosis Endometriosis Female Humans Interferon-gamma Interferon-gamma Lymphokines

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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