New biomarkers in endometriosis

Larissa Milani Coutinho, Coutinho LM, Larissa M Coutinho, Márcia C Ferreira, Márcia Cristina França Ferreira, Rocha ALL, Ana Luiza Lunardi Rocha, Ana Luiza L Rocha, Márcia M Carneiro, Márcia Mendonça Carneiro, Reis FM, Fernando M Reis
Advances in clinical chemistry · 2019 · vol. 89 , pp. 59–77 · doi:10.1016/bs.acc.2018.12.002 · PMID:30797471 · W2915556861
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⚙ AI-generated summary by claude@2026-06, 2026-06-18 ⓘ

This paper identified novel biomarkers that show promise for the diagnosis of endometriosis.

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Abstract

Endometriosis is a benign gynecological disorder which presents significant challenges in terms of diagnosis and management. Despite decades of research, there are no sufficiently sensitive and specific signs and symptoms nor blood tests for the clinical confirmation of endometriosis, which hampers prompt diagnosis and treatment. The huge majority of potential biomarkers has been discarded in research stage and very few have been translated to clinical practice. Serum CA-125 is the most studied and used one, but studies have shown its poor diagnostic performance. Several factors involved in the chronic inflammatory process of endometriosis, such as hormones, cytokines, chemokines, angiogenic factors, oxidative stress markers and others, have been implicated in the disease's pathogenesis and have been extensively studied, but not a single one has successfully been able to accurately identify the disease. MicroRNAs have emerged more recently but their utility to detect endometriosis remains uncertain. The search for a biomarker or a set of biomarkers is still open and may benefit from novel molecular biology and bioinformatics approaches to mine and uncover molecular signatures specifically associated with the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Angiogenic Proteins Angiogenic Proteins Animals Biomarkers Biomarkers Cytokines Cytokines Endometriosis Endometriosis Female Glycoproteins Glycoproteins Hormones Hormones Humans MicroRNAs MicroRNAs Uterus Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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