Current biomarkers for the detection of endometriosis

Zhao Tian, Xiao-Hong Chang, Xiaohong Chang, Yan Zhao, Hong-Lan Zhu, Honglan Zhu
Chinese medical journal · 2020 · vol. 133(19) , pp. 2346–2352 · doi:10.1097/cm9.0000000000001063 · PMID:32858595 · W3082382475
article OA: gold CC0 ⤵ 32 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Despite extensive research into hundreds of biomarkers, including CA-125 and IL-6, no clinically reliable non-invasive tests for endometriosis have been confirmed, though emerging "omics" and imaging technologies show promise.

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Abstract

A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic delay. Although varieties of biomarkers have been investigated for decades, and cancer antigen-125, cancer antigen-199, interleukin-6, and urocortin were the most studied ones among hundreds of biomarkers, no clinically reliable biomarkers have been confirmed so far. Some emerging technologies including "omics" technologies, molecular imaging techniques, and microRNAs are promising in solving these challenges, but their utility to detect endometriosis has yet to be verified. New combinations of researched indicators or other non-invasive methods and further exploration of the emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of endometriosis. In conclusion, researches of biomarkers for the detection of endometriosis are still ongoing and may benefit from novel molecular biology, bioinformatics methods and a combination of more diverse monitoring methods. Though it will be a daunting task, the identification of a specific set of diagnostic biomarkers will undoubtedly improve the status of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis MicroRNAs Biomarkers CA-125 Antigen Delayed Diagnosis Female Humans Interleukin-6

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (71)

Cited by (32)

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