The SPRi determination of cathepsin L and S in plasma and peritoneal fluid of women with endometriosis

Załęcka J, Julia Załęcka, Zuzanna Zielińska, Zielińska Z, Łukasz Ołdak, Agata Sakowicz, Grzegorz Mańka, Mańka G, Kiecka M, Mariusz Kiecka, Robert Spaczyński, Spaczyński R, Piekarski P, Piotr Piekarski, Banaszewska B, Beata Banaszewska, Jakimiuk A, Artur Jakimiuk, Issat T, Tadeusz Issat, Jakub Młodawski, Młodawski J, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Raba G, Szczupak K, Kamil Szczupak, Tomasz Kluz, Kluza M, Marek Kluza, Piotr Pierzyński, Pierzyński P, Michał Ciebiera, Ciebiera M, Wojtyła C, Cezary Wojtyła, Michał Lipa, Damian Warzecha, Warzecha D, Wielgoś M, Mirosław Wielgoś, Cendrowski K, Krzysztof Cendrowski, Ewa Gorodkiewicz, Gorodkiewicz E, Piotr Laudański
Advances in medical sciences · 2024 · vol. 69(2) , pp. 224–230 · doi:10.1016/j.advms.2024.04.004 · PMID:38642611 · W4394913071
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study used SPRi to quantify cathepsin L and S levels in plasma and peritoneal fluid samples from women diagnosed with endometriosis.

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Abstract

PURPOSE: Endometriosis is a common disease with a complex pathomechanism and atypical symptoms, often leading to delayed diagnosis. Currently, the sole method for confirming the presence of the disease is through laparoscopy and histopathological examination of collected tissue. However, this invasive procedure carries potential risk and complications, necessitating the exploration of non-surgical diagnostic methods for endometriosis. This study aims to analyze peritoneal fluid and plasma samples for the expression of cathepsin L and cathepsin S to identify potential biomarkers for non-invasive diagnostic approaches to endometriosis. MATERIAL AND METHODS: In this cross-sectional study, plasma and peritoneal fluid samples were obtained during laparoscopy from 63 patients diagnosed with chronic pelvic pain or infertility. The study group consisted of women with confirmed endometriosis. The concentrations of cathepsins L and S were determined using an SPRi biosensor. RESULTS: The study did not reveal significant differences in the concentrations of cathepsin L and cathepsin S between the control group and the study group, both in peritoneal fluid and plasma. CONCLUSIONS: Based on the results of this study, it appears that cathepsins L and S are not suitable candidates as biomarkers for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (62)

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