Profiling of Selected MicroRNAs in Proliferative Eutopic Endometrium of Women with Ovarian Endometriosis

Piotr Laudański, P Laudanski, R Charkiewicz, Radosław Charkiewicz, Agnieszka Tołwińska, A Tolwinska, Jacek Szamatowicz, J Szamatowicz, A Charkiewicz, Angelika Edyta Charkiewicz, J Niklinski, Jacek Nikliński
BioMed research international · 2015 · vol. 2015 , pp. 1–10 · doi:10.1155/2015/760698 · PMID:26366419 · PMC4558423 · W1622700982
article OA: gold CC0 ⤵ 34 in-corpus citations
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This study compared microRNA expression in the endometrium of women with and without endometriosis, identifying 1198 significantly altered microRNAs and 136 with a fold change of at least 1.3.

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Abstract

It has been well documented that aberrant expression of selected microRNAs (miRNAs) might contribute to the pathogenesis of disease. The aim of the present study is to compare miRNA expression by the most comprehensive locked-nucleic acid (LNA) miRNA microarray in eutopic endometrium of patients with endometriosis and control. In the study we recruited 21 patients with endometriosis and 25 were disease-free women. The miRNA expression profiles were determined using the LNA miRNA microarray and validated for selected molecules by real-time PCR. We identified 1198 human miRNAs significantly differentially altered in endometriosis versus control samples using false discovery rate of <5%. However only 136 miRNAs showed differential regulation by fold change of at least 1.3. By the use of selected statistical analysis we obtained 45 potential pathways that might play a role in the pathogenesis of endometriosis. We also found that natural killer cell mediated cytotoxicity pathway was found to be inhibited which is consistent with previous studies. There are several pathways that may be potentially dysregulated, due to abnormal miRNA expression, in eutopic endometrium of patients with endometriosis and in this way contribute to its pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Cell Proliferation Endometriosis Endometriosis Endometrium MicroRNAs Ovary Adult Case-Control Studies Cell Proliferation Endometriosis Endometrium Female Gene Expression Profiling Gene Expression Profiling Humans MicroRNAs Ovary

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References (43)

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