"Shadow of a Doubt"-The Pathogenic Role of Endometrial Defects in Endometriosis Development and Endometriosis-Associated Infertility: Robust Demonstration of Clinical Relevance Is Still Urgently Needed

Paola Viganò, Maíra Casalechi, Paolo Vercellini, Edgardo Somigliana, Somigliana E
Biomolecules · 2023 · vol. 13(4) , pp. 651 · doi:10.3390/biom13040651 · PMID:37189399 · PMC10135529 · W4362609002
editorial OA: gold CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review explores the pathogenic role of endometrial defects in endometriosis development and associated infertility, emphasizing the urgent need for robust clinical relevance demonstrations.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-10 · read from full text ⓘ

This paper discusses the proposed pathogenic role of endometrial defects in the development of endometriosis and in endometriosis-associated infertility, with an emphasis on the need for stronger clinical evidence linking these mechanisms to patient outcomes. It is presented as a conceptual/clinical-relevance argument rather than a new experimental study, reviewing why robust demonstration in relevant cohorts remains urgently needed. The paper’s major limitation is that it underscores the gap in definitive clinical validation rather than providing new data that resolves it. This paper is centrally about endometriosis — specifically the role of endometrial defects in endometriosis development and related infertility, and the need for clearer clinical confirmation.

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Abstract

Endometriosis is an estrogen-dependent chronic inflammatory disease characterized by the presence of endometrial glands and stroma associated with fibrosis outside the uterine cavity [...].
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Author

Conceptualization, P.V. (Paola Viganò); writing—original draft preparation, P.V.(Paola Viganò); writing—review and editing, M.C., P.V. (Paolo Vercellini), E.S. All authors have read and agreed to the published version of the manuscript.

Funding

This study was funded by Italian Ministry of Health—Current research IRCCS; M.C. acknowledges the support of Coordenação de Aperfeiçoamento de Pessoal do Nível Superior-Brasil (CAPES)—Finance Code 001.

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Conflicts

The authors declare no conflict of interest.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

Cited by (6)

Source provenance

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