Impact of endometriosis on oocyte quality in women undergoing assisted reproduction

Parimala Chinta, Chinta P, Treasa Joseph, Joseph T, Nadia Imam, Imam N, Nikhil Gupta, Gupta N, Nivedita Gupta, H Mohan, Mohan H, Hemapriya MOHAN, Mohan Shashikanth Kamath, Kamath MS, Mohan S. Kamath
Minerva obstetrics and gynecology · 2024 · vol. 77(3) , pp. 205–214 · doi:10.23736/s2724-606x.24.05552-0 · PMID:39625420 · W4404961833
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This review examines how endometriosis affects oocyte quality, embryo quality, and endometrial receptivity in assisted reproduction, suggesting reduced oocyte yield may be the primary factor impacting success.

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Abstract

Endometriosis is a chronic gynecological condition which can lead to infertility in women during reproductive age. Endometriosis influences the assisted reproductive technology (ART) outcomes by its impact on oocyte and embryo quality, oocyte numbers and subsequently the embryo numbers and endometrial receptivity. There has been clinical dilemma as to whether it is predominantly the oocyte, or the endometrium which affects the pregnancy outcomes in women with endometriosis. In this review we provide an overview of the effect of endometriosis on the oocyte molecular mechanism, the overall effect of endometriosis and its various stages as well as the effect of endometrioma on the oocyte quality in autologous study models. We have also provided a review of the donor oocyte models to study the effect of endometriosis on the endometrium. While initial small donor oocyte-based model studies suggested a possible major detrimental impact of oocyte quality on ART outcomes in women with endometriosis, the more recent studies have found minimal or no impact of oocyte quality on treatment outcomes. There is growing evidence to suggest an important contributory role of reduced oocyte yield on ART success in women with endometriosis. There is a need to explore whether oocyte yield and not the oocyte quality or endometrial receptivity, is the main reason for lower success in women with endometriosis following ART.
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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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