Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis

P Laudanski, Piotr Laudański, Jacek Szamatowicz, J Szamatowicz, O Kowalczuk, Oksana Kowalczuk, M Kuźmicki, Mariusz Kuźmicki, Marcin Grabowicz, M Grabowicz, L Chyczewski
Human Reproduction · 2009 · vol. 24(8) , pp. 1880–1890 · doi:10.1093/humrep/dep175 · PMID:19429661 · W2122998411
article OA: bronze CC0 ⤵ 48 in-corpus citations
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This study found significantly higher AKT1 and 4EBP1 mRNA levels in the eutopic endometrium of women with endometriosis compared to controls.

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Abstract

BACKGROUND: It is becoming increasingly evident that the eutopic endometrium of women with endometriosis shows certain genetic alterations which are not found in the endometrium of disease-free women. The aim of the study was to compare the expression level of mammalian target of rapamycin (mTOR) tumor suppressor and oncogene-related genes in the endometrium of women with and without endometriosis as well as in ovarian endometriosis. METHODS: A total of 81 regularly menstruating patients were recruited in the study. We applied the micro fluidic gene array to examine the expression of 15 human tumor suppressor and oncogenes in eutopic endometrium of 40 women with endometriosis and 41 controls without endometriosis. In 14 patients with endometriosis, gene expression was also studied in matched ovarian lesions. We studied the following genes: NF1, RHEB, mTOR, PTEN, TSC1, TSC2, KRAS, S6K1, TP53, EIF4E, LKB1, PIK3CA, BECN1, 4EBP1 and AKT1. Immunohistochemical studies were subsequently performed for selected proteins. RESULTS: Of the 15 studied genes, we found significantly higher levels of oncogene AKT1 (P = 0.006) and tumor suppressor gene 4EBP1 (P = 0.01) mRNAs in the eutopic endometrium of women with endometriosis compared with control patients. Immunohistochemistry showed that 4EBP1 and AKT1 proteins were expressed in eutopic endometrium. CONCLUSIONS: Our results suggest that up-regulation of AKT1 and 4EBP1 in eutopic endometrium may be associated with the pathogenesis of endometriosis, but their precise role remains to be established.

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Condition tags

endometriosis

MeSH descriptors

Adaptor Proteins, Signal Transducing Endometriosis Endometrium Gene Expression Profiling Genes, Tumor Suppressor Oncogenes Phosphoproteins Protein Kinases Proto-Oncogene Proteins c-akt Adaptor Proteins, Signal Transducing Adult Cell Cycle Proteins Endometriosis Endometriosis Endometrium Female Genes, Tumor Suppressor Humans Oncogenes Phosphoproteins

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (48)

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