Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis

Izyan Nabila Ahmad Azam, Norhazlina Abdul Wahab, Mohd Helmy Mokhtar, Mohamad Nasir Shafiee, Norfilza Mohd Mokhtar
Life (Basel, Switzerland) · 2022 · vol. 12(9) , pp. 1321 · doi:10.3390/life12091321 · PMID:36143357 · W4293758592
review OA: gold CC0 ⤵ 13 in-corpus citations
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This review highlights dysregulated microRNAs and their target genes in endometriosis, focusing on their roles in apoptosis regulation and their potential as diagnostic biomarkers and therapeutic targets.

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Abstract

Endometriosis is a gynecologic disorder characterized by the presence of endometrial tissues outside the uterine cavity affecting reproductive-aged women. Previous studies have shown that microRNAs and their target mRNAs are expressed differently in endometriosis, suggesting that this molecule may play a role in the development and persistence of endometriotic lesions. microRNA (miRNA), a small non-coding RNA fragment, regulates cellular functions such as cell proliferation, differentiation, and apoptosis by the post-transcriptional modulation of gene expression. In this review, we focused on the dysregulated miRNAs in women with endometriosis and their roles in the regulation of apoptosis. The dysregulated miRNAs and their target genes in this pathophysiology were highlighted. Circulating miRNAs as potential biomarkers for the diagnosis of endometriosis have also been identified. As shown by various studies, miRNAs were reported to be a potent regulator of gene expression in endometriosis; thus, identifying the dysregulated miRNAs and their target genes could help discover new therapeutic targets for treating this disease. The goal of this review is to draw attention to the functions that miRNAs play in the pathophysiology of endometriosis, particularly those that govern cell death.

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endometriosis

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