Progesterone Resistance in Endometriosis: an Acquired Property?

Brett McKinnon; Michael D. Mueller; Michael Mueller; Mueller M; Montgomery G; Grant W. Montgomery; Grant Montgomery

doi:10.1016/j.tem.2018.05.006

Progesterone Resistance in Endometriosis: an Acquired Property?

Brett McKinnon, Michael D. Mueller, Michael Mueller, Mueller M, Montgomery G, Grant W. Montgomery, Grant Montgomery

Trends in endocrinology and metabolism: TEM · 2018 · vol. 29(8) , pp. 535–548 · doi:10.1016/j.tem.2018.05.006 · PMID:29934050 · W2808923566

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This study investigates whether progesterone resistance in endometriosis is an acquired characteristic rather than an intrinsic one.

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Abstract

Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate, acquired, or present in both the eutopic and ectopic tissue in not always clear. We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. This suggests more studies are required in eutopic tissue particularly, and that potentially the suppressed progesterone receptor (PR) expression is a consequence of the pathogenic process and exposure to the peritoneal environment.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Gene Expression Receptors, Progesterone Uterine Diseases Endometriosis Endometrium Female Humans Receptors, Progesterone Uterine Diseases

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Cited by (50)

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