Dominant Expression of Progesterone Receptor Form B mRNA in Ovarian Endometriosis

R Misao, Ryou Misao, Shigenori Iwagaki, S Iwagaki, J Fujimoto, Jiro Fujimoto, Wen-Shu Sun, W Sun, Teruhiko Tamaya, T Tamaya
Hormone research · 1999 · vol. 52(1) , pp. 30–34 · doi:10.1159/000023429 · PMID:10640897 · W2020976980
article OA: closed CC0 ⤵ 29 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found a significantly higher ratio of PR-B to PR-A/B mRNA expression in ovarian endometriosis compared to eutopic endometrium, potentially affecting progestational responses.

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Abstract

This study was designed to examine the biological implications of progesterone receptor form A (PR-A) and B (PR-B) mRNA expressions in human ovarian endometriosis (ectopic endometrium). A high ratio of PR-B to PR-AB (PR-A+PR-B) mRNA expression was found in 8 of 14 cases of endometriosis, compared with the ratio in eutopic endometrium. The mean ratio in ectopic endometria was significantly (p < 0.01) higher than in eutopic endometria. The ratio in eutopic and ectopic endometria showed no significant change during the menstrual cycle. The mean ratio in ectopic endometria in the proliferative and secretory phases of the endometrium was significantly (p < 0.01) higher than in eutopic endometria. In conclusion, PR-B mRNA was relatively highly expressed in some endometriomas, which might lead to aberrations in the control of progestational effects involving responsiveness to sex steroidal growth regulation.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Receptors, Progesterone RNA, Messenger Adult Endometriosis Female Gene Expression Regulation, Neoplastic Humans Middle Aged Ovarian Diseases Receptors, Progesterone Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (29)

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