Disrupted Cell Cycle Control in Cultured Endometrial Cells from Patients with Endometriosis Harboring the Progesterone Receptor Polymorphism PROGINS

Paulo D'Amora, Paulo D’Amora, Thiago Trovati Maciel, Tambellini R, Rodrigo Tambellini, Marcelo A. Mori, João Bosco Pesquero, Hélio Sato, Helio Sato, Sato H, Manoel João Batista Castello Girão, Girão Mj, Manoel Joâo Batista Castello Girão, Ismael Dale Cotrim Guerreiro da Silva, Guerreiro da Silva ID, Eduardo Schor, Schor E
The American Journal of Pathology · 2009 · vol. 175(1) , pp. 215–224 · doi:10.2353/ajpath.2009.080966 · PMID:19497994 · PMC2708808 · W1994392455
article OA: bronze CC0 ⤵ 23 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated how the PROGINS polymorphism in the progesterone receptor gene affects cell cycle control in cultured endometrial cells from women with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Presently, little is understood about how endometriosis is established or maintained, or how genetic factors can predispose women to the disease. Because of the crucial role that the progesterone receptor polymorphism PROGINS plays in predisposing women to the development of endometriosis, we hypothesized that this variant may influence critical steps during endometrial cell metabolism that are involved in the pathogenesis of endometriosis. Eutopic endometria were collected from three sources: women with endometriosis who had a single PROGINS allele (from the progesterone receptor gene); women with endometriosis who had the wild-type progesterone receptor allele; and women without endometriosis who had the wild-type allele. Cells prepared from the eutopic endometria of these women were stimulated with both estradiol and progesterone, and then examined for cell proliferation, viability, and apoptosis. The cells from women with endometriosis that carried the PROGINS allele demonstrated increased proliferation, greater viability, and decreased apoptosis following progesterone treatment. In general, these parameters were very different as compared with those of women with endometriosis but without the PROGINS allele and women in the control group. This result indicates there is a reduced level of progesterone responsiveness in women who carry the PROGINS polymorphism. Because progesterone responsiveness is known to be an important characteristic of women with endometriosis, these data support the contention that the PROGINS polymorphism enhances the endometriosis phenotype.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cell Cycle Endometriosis Genetic Predisposition to Disease Polymorphism, Genetic Receptors, Progesterone Adult Apoptosis Apoptosis Apoptosis Cell Cycle Cell Cycle Cell Proliferation Cell Proliferation Cells, Cultured Cell Survival Endometriosis Female Flow Cytometry Humans Progesterone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (69)

Cited by (24)

Source provenance

europepmc
last seen: 2026-09-04T06:17:57.233406+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:05.573375+00:00
License: CC0 · commercial use OK