Emerging hallmarks of endometriosis metabolism: A promising target for the treatment of endometriosis

Lu J; Jiayi Lu; Ling X; Xi Ling; Liu L; Lu Liu; Aifang Jiang; Jiang A; Ren C; Chune Ren; Chao Lü; Lu C; Chao Lu; Yu Z; Zhenhai Yu

doi:10.1016/j.bbamcr.2022.119381

Emerging hallmarks of endometriosis metabolism: A promising target for the treatment of endometriosis

Lu J, Jiayi Lu, Ling X, Xi Ling, Liu L, Lu Liu, Aifang Jiang, Jiang A, Ren C, Chune Ren, Chao Lü, Lu C, Chao Lu, Yu Z, Zhenhai Yu

Biochimica et biophysica acta. Molecular cell research · 2022 · vol. 1870(1) , pp. 119381 · doi:10.1016/j.bbamcr.2022.119381 · PMID:36265657 · W4306407495

review OA: closed CC0 ⤵ 19 in-corpus citations

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This review discusses emerging metabolic hallmarks of endometriosis, identifying promising targets for therapeutic intervention.

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Abstract

Endometriosis, characterized by ectopic endometrium growth in the extrauterine environment, is one of the most notable diseases of the female reproductive system. Worldwide, endometriosis affects nearly 10 % of women in their reproductive years and causes a significant decline in quality of life. Despite extensive investigations of endometriosis over the past years, the mechanisms of endometriosis pathogenesis remain unclear. In recent years, metabolic factors have increasingly been considered factors in endometriosis. There is compelling evidence regarding the progress of endometriosis in the context of severe metabolic dysfunction. Hence, the curative strategies and ongoing attempts to conquer endometriosis might start with metabolic pathways. This review focuses on metabolic mechanisms and summarizes current research progress. These findings provide valuable information for the non-intrusive diagnosis of the disease and may contribute to the understanding of the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (24)

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[1] 1H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis via openalex

[2] Accurate diagnosis of endometriosis using serum microRNAs via openalex

[3] A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis via openalex

[4] Adjuvant use of melatonin for pain management in dysmenorrhea — a randomized double-blinded, placebo-controlled trial via openalex

[5] Advances in the medical treatment of adolescent endometriosis via openalex

[6] Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis via openalex

[7] Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis via openalex

[8] Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis via openalex

[9] Analysis of the ectoenzymes ADA, ALP, ENPP1, and ENPP3, in the contents of ovarian endometriomas as candidate biomarkers of endometriosis via openalex

[10] Analysis of vitamin D-binding protein (VDBP) gene polymorphisms in Korean women with and without endometriosis via openalex

[11] An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis via openalex

[12] Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota via openalex

[13] Antioxidant supplementation reduces endometriosis-related pelvic pain in humans via openalex

[14] Antiproliferative effects of anastrozole, methotrexate, and 5-fluorouracil on endometriosis in vitro and in vivo via openalex

[15] A Prospective Cohort Study of Vitamins B, C, E, and Multivitamin Intake and Endometriosis via openalex

[16] Association between mitochondrial DNA D-loop region polymorphisms and endometriosis in a Chinese population via openalex

[17] Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis via openalex

[18] Associations Between Endometriosis and Gut Microbiota via openalex

[19] Association study of the<i>TNF-α</i>−1031T/C and<i>VEGF</i> + 450G/C polymorphisms with susceptibility to endometriosis via openalex

[20] Bis-Indole–Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis via openalex

[21] Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets? via openalex

[22] Cinnamic acid inhibits cell viability, invasion, and glycolysis in primary endometrial stromal cells by suppressing NF-κB-induced transcription of PKM2 via openalex

[23] Combination Effect of Caffeine and Caffeic Acid Treatment on the Oxidant Status of Ectopic Endometrial Cells Separated from Patients with Endometriosis. via openalex

[24] Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis via openalex

[25] Correlation of fecal metabolomics and gut microbiota in mice with endometriosis via openalex

[26] Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study via openalex

[27] Curcumin and Endometriosis via openalex

[28] Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis: A Prospective Cohort Study via openalex

[29] Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375 via openalex

[30] Discovery of Phosphatidic Acid, Phosphatidylcholine, and Phosphatidylserine as Biomarkers for Early Diagnosis of Endometriosis via openalex

[31] Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis via openalex

[32] Disrupted Cell Cycle Control in Cultured Endometrial Cells from Patients with Endometriosis Harboring the Progesterone Receptor Polymorphism PROGINS via openalex

[33] Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS? via openalex

[34] Dysregulated Sphingolipid Metabolism in Endometriosis via openalex

[35] Effect of melatonin for the management of endometriosis: a protocol of systematic review and meta-analysis via openalex

[36] Effect of simvastatin on baboon endometriosis† via openalex

[37] Effects of danazol and lynestrenol on serum lipoproteins in endometriosis via openalex

[38] Effects of danazol on plasma lipid and lipoprotein levels in healthy women and in women with endometriosis via openalex

[39] Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model via openalex

[40] Effects of vitamin C on the outcome of in vitro fertilization–embryo transfer in endometriosis: A randomized controlled study via openalex

[41] Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial via openalex

[42] Elevated serum lipoprotein(a) levels in young women with endometriosis via openalex

[43] Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis via openalex

[44] Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels via openalex

[45] Endometriosis associated with the N314D mutation of galactose-1-phosphate uridyl transferase (GALT) via openalex

[46] Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action via openalex

[47] Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry via openalex

[48] Endometriosis induces gut microbiota alterations in mice via openalex

[49] Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (HMOX1) Gene via openalex

[50] Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation via openalex

[51] Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance via openalex

[52] Endometriosis: The Role of Iron Overload and Ferroptosis via openalex

[53] Endometriosis: The Ultimate Hormonal Disease via openalex

[54] Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model via openalex

[55] Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis via openalex

[56] Estrogen biosynthesis and signaling in endometriosis via openalex

[57] Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance via openalex

[58] Estrogen metabolism and action in endometriosis via openalex

[59] Estrogen metabolizing enzymes in endometrium and endometriosis via openalex

[60] Estrogen Production and Metabolism in Endometriosis via openalex

[61] Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome via openalex

[62] Expression of Aromatase and Estrogen Sulfotransferase in Eutopic and Ectopic Endometrium: Evidence for Unbalanced Estradiol Production in Endometriosis via openalex

[63] Functional Analyses of Endometriosis-Related Polymorphisms in the Estrogen Synthesis and Metabolism-Related Genes via openalex

[64] Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes via openalex

[65] Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis via openalex

[66] Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions via openalex

[67] Glutathione-S-transferase P1 gene polymorphism and susceptibility to endometriosis via openalex

[68] Gut Microbiota Exceeds Cervical Microbiota for Early Diagnosis of Endometriosis via openalex

[69] Hidrox® and Endometriosis: Biochemical Evaluation of Oxidative Stress and Pain via openalex

[70] HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility via openalex

[71] HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression via openalex

[72] Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections via openalex

[73] Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis via openalex

[74] I405V polymorphism of<i>CETP</i>gene and lipid profile in women with endometriosis via openalex

[75] Identification of candidate microRNA markers of endometriosis with the use of next-generation sequencing and quantitative real-time polymerase chain reaction via openalex

[76] Immunomodulatory effects of vitamin D3 on gene expression of MDGF, EGF and PDGFB in endometriosis via openalex

[77] Increased concentration of 8-hydroxy-2′-deoxyguanosine in follicular fluid of infertile women with endometriosis via openalex

[78] Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism via openalex

[79] Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. via openalex

[80] Influence of Stress on the Vitamin D-Vitamin D Receptor System, Macrophages, and the Local Inflammatory Milieu in Endometriosis via openalex

[81] Inhibition of Type 1 17β-Hydroxysteroid Dehydrogenase Impairs the Synthesis of 17β-Estradiol in Endometriosis Lesions via openalex

[82] Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions via openalex

[83] Intricate Connections between the Microbiota and Endometriosis via openalex

[84] Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1 via openalex

[85] Iron overload–modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis via openalex

[86] Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid via openalex

[87] Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis? via openalex

[88] Is there a Relationship Between Vitamin D and Endometriosis? An Overview of the Literature via openalex

[89] Lack of association between <scp>LIPC</scp>‐514 <scp>C/T</scp> polymorphism of hepatic lipase and endometriosis in <scp>I</scp>ranian women via openalex

[90] Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study via openalex

[91] Lipid peroxidation in the peritoneal fluid of infertile women with peritoneal endometriosis via openalex

[92] Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells via openalex

[93] Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate via openalex

[94] Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1 via openalex

[95] Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis via openalex

[96] Measurable serum markers of oxidative stress response in women with endometriosis via openalex

[97] Melatonin activity and receptor expression in endometrial tissue and endometriosis via openalex

[98] Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases via openalex

[99] Melatonin inhibits 17β-estradiol-induced migration, invasion and epithelial-mesenchymal transition in normal and endometriotic endometrial epithelial cells via openalex

[100] Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms via openalex