Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS?

Neli Hevir, Martina Ribič-Pucelj, Tea Lanišnik Rižner
Molecular and cellular endocrinology · 2012 · vol. 367(1-2) , pp. 74–84 · doi:10.1016/j.mce.2012.12.019 · PMID:23277161 · W2000224370
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the balance of phase I and II metabolizing enzymes in ovarian endometriosis, hypothesizing a potential link to excessive hydroxy-estrogens and reactive oxygen species (ROS).

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Estrogens Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Ovary Reactive Oxygen Species Adult Aryl Hydrocarbon Hydroxylases Aryl Hydrocarbon Hydroxylases Aryl Hydrocarbon Hydroxylases Blotting, Western Case-Control Studies Catechol O-Methyltransferase Catechol O-Methyltransferase Catechol O-Methyltransferase Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1

Citation neighborhood

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References (53)

Cited by (23)

Source provenance

europepmc
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License: CC0 · commercial use OK