Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis

Vouk K, Katja Vouk, Tina Smuc, Smuc T, Tina Šmuc, Guggenberger C, Christina Guggenberger, Martina Ribič-Pucelj, Ribič-Pucelj M, Jasna Šinkovec, Jasna Sinkovec, Sinkovec J, Bettina Husen, Husen B, Thole H, Hubert Thole, Pieter Houba, Houba P, Pieter H.J. Houba, Claudia Thaete, Jerzy Adamski, Tea Lanišnik Rižner, Rižner TL
The Journal of steroid biochemistry and molecular biology · 2011 · vol. 125(3-5) , pp. 231–242 · doi:10.1016/j.jsbmb.2011.03.010 · PMID:21397694 · W2002208145
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Differential expression analysis of 172 selected genes in ovarian endometriosis samples revealed 78 differentially expressed genes, including 32 novel estrogen-related genes, potentially serving as biomarkers.

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Abstract

In the search for novel biomarkers of endometriosis, we selected 152 genes from the GeneLogic database based on results of genome-wide expression analysis of ovarian endometriosis, plus 20 genes related to estrogen metabolism and action. We then performed low-density array analysis of these 172 genes on 11 ovarian endometriosis samples and 9 control endometrium samples. Principal component analysis of the gene expression levels showed clear separation between the endometriosis and control groups. We identified 78 genes as differentially expressed. Based on Ingenuity pathway analysis, these differentially expressed genes were arranged into groups according to biological function. These analyses revealed that 32 differentially expressed genes are estrogen related, 23 of which have not been reported previously in connection with endometriosis. Functional annotation showed that 25 and 22 genes are associated with the biological terms "secreted" and "extracellular region", respectively. Differential expression of 4 out of 5 genes related to estrogen metabolism and action (ESR1, ESR2, PGR and BGN) was also confirmed by immunohistochemistry. Our study thus reveals differential expression of several genes that have not previously been associated with endometriosis and that encode potential novel biomarkers and drug targets.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometriosis Adult Aromatase Aromatase Aromatase Biglycan Biglycan Biglycan Biomarkers Endometriosis Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor alpha Female Humans Immunohistochemistry In Vitro Techniques Middle Aged

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