Endometriosis: Pathogenesis, Diagnosis and Treatment, volume II
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This paper is a research-topic call describing the state of knowledge and research priorities for endometriosis, focusing on pathogenesis, diagnosis, and treatment. It outlines clinical approaches such as transvaginal ultrasonography as first-line imaging, MRI/virtual colonoscopy for suspected bowel or urinary tract disease, hormonal therapy as first-line pain treatment (with combined estroprogestins/progestins and second-line GnRH analogues/antagonists), and mentions aromatase inhibitors as proposed but not approved outside scientific research; it also notes that hormonal therapy is not curative and symptoms often recur after stopping. Surgical excision is described as an option for persistent pain or refusal of hormonal therapies, with the caveat that procedures are challenging and recurrence can occur, and it states that infertility is usually treated with in vitro fertilization while the role of pre-treatment hormonal therapy is unclear. This paper is centrally about endometriosis — it serves as a Frontiers in Endocrinology Research Topic overview on endometriosis pathogenesis, diagnosis, and treatment.
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