Endometriosis: A Role for Stem Cells

Amy S Dhesi, Sara S Morelli
Women's health (London, England) · 2015 · vol. 11(1) , pp. 35–49 · doi:10.2217/whe.14.57 · PMID:25581054 · W2083398572
review OA: gold CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Evidence suggests endometrial stem cells play a key role in the pathogenesis of endometriosis, with endothelial progenitor cells potentially involved in new blood vessel formation supporting endometriotic implants.

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Abstract

Endometriosis is a complex gynecologic condition affecting 6-10% of reproductive aged women and is a major cause of chronic pain and infertility. Mechanisms of disease pathogenesis are poorly understood. Considerable evidence supports the existence of a stem cell population in the endometrium which provides a physiologic source of regenerative endometrial cells, and multiple lines of evidence now support a key role for stem cells in the pathogenesis of endometriosis. In addition, new blood vessel formation is critical for the establishment and maintenance of endometriotic implants, a process in which endothelial progenitor cells may play an integral role. These new insights into disease pathogenesis present exciting opportunities to develop targeted and more effective therapeutic options in the management of this common and challenging disease.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Regeneration Stem Cells Endometriosis Endometriosis Endometrium Endometrium Female Humans Menstruation Disturbances Regeneration Stem Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (16)

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