Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts.

Haruko Jimbo, H Jimbo, Y Hitomi, Hiroyuki Yoshikawa, H Yoshikawa, T Yano, Mikio Momoeda, M Momoeda, A Sakamoto, Atsuhiko Sakamoto, Osamu Tsutsumi, O Tsutsumi, Y Taketani, Yuji Taketani, Hiroyasu Esumi, H Esumi
The American journal of pathology · 1997 · vol. 150(4) , pp. 1173–8 · PMID:9094973 · W69814473
article OA: green CC0 ⤵ 103 in-corpus citations
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Analysis of the human androgen receptor gene in epithelial cells from ovarian endometrial cysts revealed monoclonal origin in all samples, suggesting neoplastic potential.

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Abstract

Ovarian endometrial cysts, one of the typical manifestations of endometriosis, are generated by the retention of cyclic hemorrhages and are classified as tumor-like lesions rather than neoplasms. Clonality analysis provides important information about the histogenesis and progression of neoplastic diseases. As it is generally accepted that most neoplasms are monoclonal in origin, however, the clonality of endometrial cysts remains uncertain. Using the human androgen receptor gene (HUMARA) as an X-linked polymorphic marker, we examined the clonal status of epithelial cells in endometrial cysts. We separated 21 fresh epithelial cell samples from 11 endometrial cysts and found that all were monoclonal in the methylation pattern of the HUMARA alleles. Moreover, in each of the five cysts from which epithelial cells were sampled from multiple and distant areas, the methylation patterns of all samples from a single cyst were identical. These data indicate that endometrial cysts are monoclonal in origin and suggest their neoplastic potentiality.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Cysts Adult Alleles Cell Division Cell Division Cell Separation Clone Cells Endometriosis Endometriosis Epithelium Epithelium Female Humans Middle Aged Ovarian Cysts Ovarian Cysts Receptors, Androgen Receptors, Androgen Sequence Analysis, DNA

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Cited by (50)

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