Ovarian Endometriotic Cysts:An Analysis of Cytologic Atypia and DNA Ploidy Patterns
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This study found that mild cytologic atypia in ovarian endometriotic cysts shows normal DNA ploidy, while severe atypia may be associated with aneuploidy, supporting the idea that atypia precedes malignancy.
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Abstract
Cytologic atypia may be seen in the glandular epithelium that lines ovarian endometriotic cysts. The significance of this atypia has not been fully elucidated. The authors studied the morphologic appearance and DNA ploidy of the glandular epithelium from 36 ovarian endometriotic cysts by image analysis on formalin-fixed paraffin-embedded tissue sections. In 29 of the cases the corresponding endometrium proper also was studied. The DNA content was diploid in all eutopic endometrium and in the lining epithelium of all endometriotic cysts without atypia or with only mild cytologic atypia. DNA aneuploidy was observed in 3 of 6 endometriotic cysts with severe atypia. Our findings indicate that mild cytologic atypia in the glandular epithelium of endometriotic cysts is associated with normal DNA ploidy patterns, whereas severe atypia may be associated with aneuploidy. These findings support the hypothesis that cytologic atypia represents the precursor lesion for the invasive epithelial malignancy that may arise in ovarian endometriotic cysts.
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Cited by (42)
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- Comparison of Clinico-Pathological Features Between Epithelial Ovarian Cancer Patients With and Without Endometriosis: A Cross-Sectional Study 2022
- Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review) 2021
- Clinical and Pathological Significance of Cellular Atypia in Endometriosis 2021
- Evaluation of PTEN and Ki67 Expression in Typical and Atypical Endometriosis and Endometriosis Associated Ovarian Cancer 2020
- Disorders of the Peritoneum 2018
- Genetics and Genomics of Endometriosis 2018
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- New knowledge and insights about the malignant transformation of endometriosis 2017
- Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas 2015
- Malignant Transformation of Endometriosis 2014
- Endometriosis: A New Cellular and Molecular Genetic Approach for Understanding the Pathogenesis and Evolutivity 2014
- Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis 2013
- Endometrioza i proces nowotworowy 2012
- Pitfalls in the diagnosis of endometriosis: a condition characterized by a plethora of unusual histological features 2011
- Endometriosis and regional lymph node involvement in a rat model 2011
- Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development 2011
- Lymphatic spread of endometriosis to pelvic sentinel lymph nodes: a prospective clinical study 2011
- Regional lymphatic spread in women with pelvic endometriosis 2011
- An investigation of basic science and clinical research methodologies to benefit clinical practice 2009
- AFECTACIÓN GANGLIONAR EN PACIENTE CON ENDOMETRIOSIS PROFUNDA RECTOVAGINAL 2009
- Endometriosis 2009
- The Role of p53 Mutation in the Carcinomas Arising from Endometriosis 2007
- KRAS variation and risk of endometriosis 2006
- Atypical Ovarian Endometriosis 2006
- Deeply infiltrating endometriosis affecting the rectum and lymph nodes 2006
- Endometriosi e cancro 2005
- Endométriome ovarien associé à une infertilité : quelle est la place de l'abstention thérapeutique? 2005
- Endometriosis and the neoplastic process 2004
- K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma 2004
- Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay 2003
- Mutagen sensitivity as a susceptibility marker for endometriosis 2003
- Malignant transformation of residual endometriosis in women on unopposed oestrogen hormone replacement therapy 2001
- Precursor lesions of ovarian epithelial malignancy 2001
- Malignant transformation of residual endometriosis in women on unopposed oestrogen hormone replacement therapy 2001
- Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis 2001
- Endometriosis: candidate genes 2001
- Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study 2000
- Cellular and Genetic Constitution of Human Endometriosis Tissues 2000
- Molecular Analysis of Clonality in Ovarian Endometrial Cysts 1999
- Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. 1997
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