Atypical Ovarian Endometriosis

Masaharu Fukunaga
In: Pathology Case Reviews · 2006 · vol. 11(1) , pp. 38–42 · doi:10.1097/01.pcr.0000196558.69330.30 · W2002219089
article OA: closed CC0 ⤵ 2 in-corpus citations
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This review discusses atypical epithelial features in ovarian endometriosis, their frequent association with clear cell and endometrioid ovarian cancers, and the potential precancerous nature of atypical endometriosis, noting shared PTEN mutations.

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Abstract

This article reviews recent advance in our understanding of ovarian endometriosis, with special reference of atypical epithelial features (atypical endometriosis) and its relationship to neoplasm. The ovary is the most common site for development of malignancy in endometriosis. Atypical glandular changes were rarely observed in ovarian endometriosis without ovarian cancer, but they were often observed associated with ovarian cancers, predominantly clear cell and endometrioid carcinomas. Atypical endometriosis can be observed in contiguity with malignant epithelial tumors. It is considered that atypical endometriosis possesses a precancerous potential. Carcinoma may arise in residual foci of atypical endometriosis at the same or other sites. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required. Endometriosis and the associated ovarian carcinomas may show identical phosphatase and tensin homolog gene (PTEN) mutations.

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endometriosis

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