Epithelial metaplastic changes in ovarian endometriosis.
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Metaplastic changes, most commonly ciliated cell and eosinophilic, were observed in 63% of ovarian endometriosis cases and were frequently associated with malignant epithelial tumors or atypia.
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Abstract
Little is known concerning epithelial metaplastic changes (metaplasia) in ovarian endometriosis. Three hundred fifteen consecutive cases of ovarian endometriosis between 1987 and 1995 were retrieved from hospital files and clinicopathologically analyzed. Two hundred fifty-seven cases were not associated with malignant ovarian epithelial tumor or atypia Four cases were atypical endometriosis. The remaining 54 cases were associated with malignant ovarian epithelial tumor, including borderline tumor. Metaplasias in ovarian endometriosis were observed in 162 (63%) cases not associated with malignant epithelial tumor or atypia. Ciliated cell and eosinophilic metaplasias were the most common (44%, respectively), followed by hobnail (13%) and mucinous (4%) types. Metaplasias in endometriosis were observed in all of the four atypical endometriosis cases and all of the 54 cases with malignant ovarian epithelial tumor. Among these cases, ciliated cell and eosinophilic metaplasia were also the most common. There was no correlation between types of carcinoma and types of metaplasia in endometriosis, but in all of the four Müllerian mucinous borderline tumors, ovarian endometriosis with mucinous metaplasia and hyperplasia was contiguous or intimately associated with the tumor. Metaplasia was often observed in ovarian endometriosis and most frequently was associated with malignant ovarian epithelial tumor or atypia. Metaplastic changes in ovarian endometriosis should not be interpreted as neoplastic features. Mucinous metaplasia and hyperplasia in ovarian endometriosis might be closely associated with the development of Müllerian mucinous borderline tumors.
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Cited by (42)
- Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum 2023
- Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum 2023
- Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features 2023
- Endometriosis and malignancy: The intriguing relationship 2021
- Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature 2021
- Folate Receptor Alpha Expression in Fallopian Tube: Further Evidence Supporting Tubal Contribution of “Ovarian” Endometriosis 2021
- Diseases of the Peritoneum 2020
- Clinically Suspected Dysgerminoma Sent for Frozen Section Confirmation: A Case With Review and Differential Diagnosis of Clear Cell Carcinoma 2020
- Use of tumor markers to distinguish endometriosis-related ovarian neoplasms from ovarian endometrioma 2020
- Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary 2019
- Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis–associated tumorigenesis 2019
- Disorders of the Peritoneum 2018
- Endometriosis-associated ovarian neoplasia 2017
- Cecal Endometriosis With Intestinal Metaplasia Misdiagnosed as Neoplasm of the Cecum by Intraoperative Histological Examination 2017
- Endometriosis‐Associated Ovarian Cancer 2014
- Pathogenesis of the Endometriosis-Related Ovarian Neoplasms 2014
- Review Article Cell origin of endometriosis: contribution by the fallopian tube epithelium 2013
- The relation between endometriosis and ovarian cancer – a review 2013
- Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis 2013
- Pathogenesis and the Role of ARID1A Mutation in Endometriosis-related Ovarian Neoplasms 2012
- No evidence of endometriosis within serous and mucinous tumors of the ovary. 2012
- Pitfalls in the diagnosis of endometriosis: a condition characterized by a plethora of unusual histological features 2011
- Endometrial metaplasias and reactive changes: a spectrum of altered differentiation 2010
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management 2009
- Endometriosis 2009
- XRCC4 codon 247*A and XRCC4 promoter −1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis 2008
- Pathology of Endometriosis and Lesions of the Secondary Müllerian System 2008
- Atypical endometriosis: a clinicopathologic study of 163 cases 2007
- Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence 2006
- Molecular genetic evidence that endometriosis is a precursor of ovarian cancer 2006
- Atypical Ovarian Endometriosis 2006
- Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and Neoplastic Transformation 2004
- Polypoid Endometriosis 2004
- Prevalence of endometriosis in malignant epithelial ovary tumours 2003
- Epithelial Abnormalities in Cystic Ovarian Endometriosis 2002
- Endometriosis: A Wide Variety of Imaging Features 2002
- Precursor lesions of ovarian epithelial malignancy 2001
- Uterus-like mass in the uterine cervix: superficial cervical endometriosis with florid smooth muscle metaplasia? 2001
- Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study 2001
- Smooth muscle metaplasia in ovarian endometriosis 2000
- Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study 2000
- Pathology of endometriosis. 1990
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