Epithelial Abnormalities in Cystic Ovarian Endometriosis

Federico Prefumo, Federica Todeschini, Todeschini F, Ezio Fulcheri, Pier Luigi Venturini, Venturini PL
Gynecologic Oncology · 2002 · vol. 84(2) , pp. 280–284 · doi:10.1006/gyno.2001.6529 · PMID:11812087 · W2094538233
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This paper details epithelial abnormalities observed in cyst samples from women with ovarian endometriosis.

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Abstract

ObjectiveTo evaluate the prevalence of epithelial abnormalities in cystic ovarian endometriosis.MethodsIn this observational study, the specimens of 388 consecutive patients undergoing a surgical procedure whose final diagnosis included cystic ovarian endometriosis were histopathologically reviewed. The prevalence and patient characteristics of cases featuring epithelial metaplasia, hyperplasia, atypia, and endometrioid carcinoma arising in endometriosis were analyzed.ResultsThe epithelial lining was evaluable in 339 cases. Left-sided cysts were significantly more common than right-sided ones (P < 0.0001). The observed prevalence was 12.1% for metaplasia, 9.4% for hyperplasia, 5.9% for atypia, and 4.1% for endometrioid carcinoma arising in endometriosis. Complex hyperplasia, but not simple hyperplasia or metaplasia, was significantly more common in cases with associated endometrioid carcinoma than in all other cases (P < 0.00001). A statistically significant trend for increasing age from normal epithelium to carcinoma was observed (P < 0.001).ConclusionsEpithelial abnormalities are a common finding in cystic ovarian endometriosis. Despite their clinical significance being still debated, complex hyperplasia and atypia can be associated with malignant transformation of endometriosis. Their observation in a surgical specimen, particularly in older patients, should indicate a careful examination of the entire lining of the cyst and a strict follow-up of the patient.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Cysts Adult Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Endometriosis Endometriosis Epithelial Cells Epithelial Cells Female Humans Middle Aged Ovarian Cysts Ovarian Cysts Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Prevalence

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK