IVF-ICSI outcome in women operated on for bilateral endometriomas

Edgardo Somigliana, Mariangela Arnoldi, Laura Benaglia, Roberta Iemmello, Anna Elisa Nicolosi, Guido Ragni, G Ragni
Human Reproduction · 2008 · vol. 23(7) , pp. 1526–1530 · doi:10.1093/humrep/den133 · PMID:18441346 · W2150854577
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Women operated on for bilateral ovarian endometriomas had significantly worse IVF-ICSI outcomes, including higher withdrawal rates, fewer follicles and oocytes, and lower pregnancy and delivery rates compared to controls.

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Abstract

BACKGROUND: The influence of previous conservative surgery for endometriomas on IVF-ICSI outcome is debated. Conflicting information emerging from the literature may be consequent to the fact that endometriomas are mostly monolateral. The contralateral intact ovary may adequately supply for the reduced function of the affected one. To clarify this point, we assess IVF-ICSI outcome in women operated on for bilateral endometriomas. METHODS: Women selected for IVF-ICSI cycles who previously underwent bilateral endometriomas cystectomy were matched (1:2) for age and study period with patients who did not undergo prior ovarian surgery. RESULTS: Sixty-eight cases and 136 controls were recruited. Women operated on for bilateral endometriotic ovarian cysts had a higher withdrawal rate for poor response (P < 0.001). In these patients, despite the use of higher doses of gonadotrophins, the number of follicles (P = 0.006), oocytes retrieved (P = 0.024) and embryos obtained (P = 0.024) were significantly lower. The clinical pregnancy rate per started cycle in cases and controls was 7% and 19% (P = 0.037) and the delivery rate per started cycle was 4% and 17%, respectively (P = 0.013). CONCLUSIONS: IVF outcome is significantly impaired in women operated on for bilateral ovarian endometriomas.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Pregnancy Rate Sperm Injections, Intracytoplasmic Treatment Outcome Adult Endometriosis Female Humans Pregnancy

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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