Effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women

Akmal El‐Mazny, Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
International journal of women's health · 2016 · vol. Volume 8 , pp. 677–682 · doi:10.2147/ijwh.s124229 · PMID:27932897 · W2558428884
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found no significant differences in uterine or ovarian blood flow parameters between infertile women with unilateral ovarian endometrioma and controls, suggesting endometriomas do not impair vascularization.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This case–control study evaluated whether unilateral ovarian endometrioma affects uterine and ovarian blood flow in 276 infertile women undergoing IVF, comparing 138 women with endometriomas to 138 women with male-factor or unexplained infertility. In the mid-luteal (peri-implantation) phase, the authors measured endometrial thickness and uterine/ovarian artery pulsatility and resistance indices, along with 3-D power Doppler virtual organ computer-aided analysis vascularization index, flow index, and vascularization flow index, using a single trained operator and reporting intraobserver reliability. They found no significant differences between groups in any Doppler or volume measures, and no changes were observed with endometrioma size or when comparing endometrioma-containing ovaries to contralateral ovaries. This paper is centrally about endometriosis — it directly tests how ovarian endometriomas relate to uterine and ovarian vascular parameters in infertile women scheduled for IVF.

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Abstract

BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility. In the mid-luteal (peri-implantation) phase of the cycle, endometrial thickness, uterine and ovarian artery pulsatility index and resistance index, endometrial and ovarian volume, 3-D power Doppler vascularization index (VI), flow index (FI), and vascularization FI (VFI) values were measured in both groups. RESULTS: >0.05) in endometrial thickness, uterine ovarian artery pulsatility index and resistance index, endometrial and ovarian volume, or VI, FI, and VFI between the two groups. Furthermore, the endometrial and ovarian Doppler indices were not influenced by endometrioma size. No significant differences were observed in the ovarian Doppler indices between endometrioma-containing ovaries and contralateral ovaries. CONCLUSION: Ovarian endometrioma is not associated with impaired endometrial and ovarian blood flows in infertile women scheduled for IVF, and it is not likely to affect endometrial receptivity or ovarian function through a vascular mechanism.

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endometriosisendometriomainfertility

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