Poor Response of Ovaries with Endometrioma Previously Treated with Cystectomy to Controlled Ovarian Hyperstimulation

Hsin-Yi Ho, Hsin‐Yi Ho, Robert Kuo-Kuang Lee, Robert Kuo‐Kuang Lee, Yuh‐Ming Hwu, Yuh-Ming Hwu, Ming-Huei Lin, Jin-Tsung Su, Yi-Chun Tsai
Journal of assisted reproduction and genetics · 2002 · vol. 19(11) , pp. 507–511 · doi:10.1023/a:1020970417778 · PMID:12484492 · PMC3455345 · W1604053463
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

Ovaries surgically treated for endometriomas showed significantly fewer dominant follicles and eggs retrieved during controlled ovarian hyperstimulation compared to the patient's contralateral normal ovary.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This retrospective study reviewed 32 women with unilateral ovarian endometrioma that had been surgically treated with cystectomy, comparing 38 cycles of controlled ovarian hyperstimulation (COH) by assessing dominant follicle numbers after hCG and the number of eggs retrieved from both the previously operated (“diseased”) ovary and the contralateral “normal” ovary in the same individuals. Ovaries with prior endometrioma cystectomy had fewer dominant follicles (1.9 ± 1.5 vs 3.3 ± 2.1) and fewer eggs retrieved at ovum pick-up (2.9 ± 2.6 vs 6.1 ± 4.1), and a greater proportion had no dominant follicles (21.1% vs 7.9%); clinical pregnancy and implantation rates per embryo transfer were also reported (33.3% and 17.6%). The authors’ key caveat is that the analysis was retrospective and thus cannot fully control for all cycle- or patient-level differences despite being paired by individual. This paper is centrally about endometriosis — it evaluates how prior cystectomy for ovarian endometrioma affects ovarian response to COH compared with the contralateral normal ovary.

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Abstract

Purpose : To compare ovarian response to controlled ovarian hyperstimulation (COH) between normal ovaries and ovaries previously treated surgically for unilateral ovarian endometrioma.

Methods

From January 1996 to December 2001, 32 patients with unilateral ovarian endometrioma previously treated surgically underwent 38 cycles of COH. Their records were reviewed retrospectively. The number of dominant follicles observed on the day of hCG injection and the number of eggs retrieved from the diseased and the normal ovaries in each patient were compared.

Results

The numbers of dominant follicles from diseased and normal ovaries were 1.9 ±1.5 and 3.3 ± 2.1, respectively (P < 0.001). During ovum pick up, the numbers of eggs retrieved from diseased and normal ovaries were 2.9 ± 2.6 and 6.1 ± 4.1, respectively (P < 0.0001). For diseased ovaries, 21.1% (8/38) had no dominant follicles, while only 7.9% (3/38) of normal ovaries lacked dominant follicles. The clinical pregnancy rate and the implantation rate per embryo transfer were 33.3 and 17.6%.

Conclusions

Surgery for ovarian endometrioma may damage ovarian reserve. It potentially results in poor ovarian response to COH, compared to the response of the contralateral normal ovary in the same individual. Similar content being viewed by others

References

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Gonadotropins Laparoscopy Laparoscopy Ovarian Diseases Ovarian Follicle Ovulation Induction Adult Embryo Transfer Endometriosis Endometriosis Female Fertilization in Vitro Gonadotropins Humans Ovarian Diseases Ovarian Diseases Ovarian Follicle Ovarian Follicle Ovarian Hyperstimulation Syndrome

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