Journal of assisted reproduction and genetics

PURPOSE: A reduced fertilization rate is a frustrating condition for patients and embryologists. This study aimed develop a statistical metric, LOW FERTILIZATION, to determine whether a distinct pathological entity underlies reduced fertili…

PURPOSE: Environmental microbiological monitoring is mandatory in IVF laboratories; however, procedure-specific risk assessment across the entire medically assisted reproduction workflow remains limited. This multicenter study, named "SMILE…

PURPOSE: To study whether there is a marked interobserver discrepancy in the diagnosis of adenomyosis based on reviewing stored sonographic images of infertile patients? METHODS: Three reproductive endocrinology and infertility specialists…

PurposeTo assess whether the endometrial receptivity analysis (ERA) captures receptivity changes attributed to endometrial aging and whether it may be useful for older patients undergoing fertility treatment.MethodsRetrospective cohort stud…

PURPOSE: To assess whether specific markers of oxidative stress and DNA damage are expressed at higher levels in primordial follicles of patients with endometriomas compared to age-matched controls. METHODS: A retrospective pilot cohort st…

PurposeInfertility affects 1 in 6 couples, yet male fertility assessments often rely on semen analysis alone, which has limited predictive value for treatment success. This study evaluates an epigenetic tool for assessing sperm quality, aim…

PurposeDoes fertility preservation (FP) through oocyte cryopreservation provide realistic reproductive opportunities for diminished ovarian reserve (DOR)? Literature suggests cumulative live birth rates of 30-45% with 8-10 oocytes under 35 …

ObjectiveTo evaluate follicular fluid (FF) SCUBE1 levels as a novel angiogenesis-associated biomarker and investigate its role in reflecting the follicular vascular microenvironment and predicting ovarian response in women undergoing assist…

The mouse embryo assay (MEA) is the standard test used in assisted reproduction to evaluate the toxicity and effectiveness of culture media and consumables. However, the assay has been criticised for its limited sensitivity, inconsistencies…

PurposeTo compare live birth rates (LBRs) between mosaic and euploid embryos.MethodsRetrospective cohort study analyzing frozen mosaic (56) and euploid (819) embryos tested with next generation sequencing, transferred between October 2018 a…

PurposeOocyte quality declines with age and metabolic stress, largely due to mitochondrial dysfunction and NAD⁺ depletion. Nicotinamide mononucleotide (NMN), a precursor of NAD⁺, has emerged as a potential intervention to restore cellular e…

PurposeTo identify treatment-related factors influencing low oocyte maturation rates in standard ovarian stimulation (OS) cycles and patients' candidates for clinical studies on rescue-IVM.MethodsRetrospective study including retrievals wit…

Background and objectiveArtificial intelligence (AI) has emerged as a promising tool for clinical decision support in reproductive medicine, yet the performance of general-purpose large language models (LLMs) in predicting in vitro fertiliz…

PURPOSE: Cancer treatments can deplete the ovarian follicle reserve, causing infertility and early menopause, with subsequent decline in cardiovascular, cognitive, and overall women's health. Medical measures to prevent this chemotherapy-in…

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have…

PURPOSE: Endometriosis (EM) is a chronic inflammatory gynecological disorder characterized by ectopic endometrial-like lesions, where aberrant angiogenesis is a hallmark driving lesion establishment and progression. However, the transcripti…

The aim of this systematic review and meta-analysis was to determine the acceptance rates and reasons for social oocyte cryopreservation (SOC) in the general population (subgroup 1) and healthcare professionals/students (subgroup 2) accordi…

PurposeThis study is to evaluate the effectiveness of a PPOS protocol in poor prognosis patients undergoing IVF with DuoStim and PGT-A versus the conventional protocol with GnRH antagonist.MethodsRetrospective cohort study encompassing 444 …

PURPOSE: To compare the effects of the gonadotrophin-releasing hormone (GnRH) agonist protocol, GnRH antagonist protocol, progestin-primed ovarian stimulation (PPOS) protocol, and mild stimulation/natural cycle protocol on the cumulative li…

PurposeTo investigate whether a premature rise in progesterone at the end of the follicular phase is adversely associated with oocyte quality in IVF cycles.MethodsA retrospective cohort study including patients less than or equal to 40 year…

PurposeAMH inhibits hormone production in luteinized granulosa cells (GCs) and stalls ovarian follicle development in vitro and in vivo. We sought to confirm AMH's mechanism of action through SMAD activation and investigate AMH inhibition o…

PurposeTo explore the impact of seasonal variations on the risks of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) in women who undergo in vitro fertilization (IVF) treatment.MethodsWe retrospectively incl…

ObjectiveTo examine the potential association between blastocyst hatching status and pregnancy outcomes following single blastocyst transfer.MethodsThis is a retrospective cohort. We screened all frozen-thawed single blastocyst transfer cyc…

PurposeTo assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET).MethodsThis is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer at …

PurposeTo evaluate the performance of different embryo transfer (ET) operators in a strictly controlled scenario minimizing potential confounders.MethodsThis single-center retrospective cohort study analyzed vitrified-warmed single euploid …