Ovarian Endometriomas Do Not Adversely Affect Pregnancy Success Following Treatment With In Vitro Fertilization

John D. Isaacs, Isaacs JD Jr, J D Isaacs, R S Hines, Randall S. Hines, Hines RS, V M Sopelak, Sopelak VM, Victoria M. Sopelak, B D Cowan, Cowan BD, Bryan D. Cowan
Journal of assisted reproduction and genetics · 1997 · vol. 14(10) , pp. 551–553 · doi:10.1023/a:1022592715006 · PMID:9447452 · PMC3454734 · W174457871
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-19 ⓘ

Aspiration of ovarian endometriomas during oocyte retrieval did not significantly affect IVF outcomes like peak estradiol, oocyte yield, or clinical pregnancy rates.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This retrospective study evaluated IVF pregnancy outcomes in 108 patients with endometriosis, comparing cycles where an ovarian endometrioma was aspirated at the time of oocyte retrieval (24 patients, 29 cycles) versus cycles without an endometrioma (84 patients, 147 cycles). Outcomes compared included peak estradiol, numbers of mature follicles, oocytes, embryos transferred, and clinical pregnancies. The study found no significant differences between groups across these measures. Limitations include its retrospective design and the small number of cycles in the endometrioma-aspirated group. This paper is centrally about endometriosis — it examines whether aspiration of ovarian endometriomas during IVF affects pregnancy success.

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Abstract

PurposeOvarian endometriomas have an uncertain impact on outcome following in vitro fertilization (IVF). Some authors describe a poor response to ovulation induction, and others observe decreased pregnancy success rates. Conversely, IVF outcomes similar to those of patients undergoing IVF for tubal-factor infertility have also been reported. To determine the impact of ovarian endometriomas on pregnancy success in our IVF program, we identified patients with endometriosis and compared outcomes that were stratified by the presence or absence of an endometrioma at the time of follicular aspiration.MethodsOne hundred eight patients with a diagnosis of endometriosis treated with IVF were identified, retrospectively. In this group, 24 patients completed 29 cycles in which an ovarian endometrioma was aspirated at the time of oocyte retrieval, and 84 patients without endometriomas completed 147 cycles. The cycles from these two groups were compared for differences in peak estradiol, number of mature follicles, number of oocytes, number of embryos transferred, and clinical pregnancies.ResultsThere were no significant differences between the two groups with respect to peak estradiol, mature follicles, number of oocytes, number of embryos transferred, or clinical pregnancies.ConclusionsFrom this retrospective observational analysis it appears that aspiration of an endometrioma at the time of oocyte retrieval has no adverse effect on outcome. This information may prove helpful when faced with the decision to cancel an IVF treatment cycle in patients with this uncommon complication.
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Abstract

Purpose: Ovarian endometriomas have an uncertain impact on outcome following in vitro fertilization (IVF). Some authors describe a poor response to ovulation induction, and others observe decreased pregnancy success rates. Conversely, IVF outcomes similar to those of patients undergoing IVF for tubal-factor infertility have also been reported. To determine the impact of ovarian endometriomas on pregnancy success in our IVF program, we identified patients with endometriosis and compared outcomes that were stratified by the presence or absence of an endometrioma at the time of follicular aspiration.

Methods

One hundred eight patients with a diagnosis of endometriosis treated with IVF were identified, retrospectively. In this group, 24 patients completed 29 cycles in which an ovarian endometrioma was aspirated at the time of oocyte retrieval, and 84 patients without endometriomas completed 147 cycles. The cycles from these two groups were compared for differences in peak estradiol, number of mature follicles, number of oocytes, number of embryos transferred, and clinical pregnancies.

Results

There were no significant differences between the two groups with respect to peak estradiol, mature follicles, number of oocytes, number of embryos transferred, or clinical pregnancies.

Conclusions

From this retrospective observational analysis it appears that aspiration of an endometrioma at the time of oocyte retrieval has no adverse effect on outcome. This information may prove helpful when faced with the decision to cancel an IVF treatment cycle in patients with this uncommon complication. Similar content being viewed by others

References

Olivennes F, Feldberg D, Liu HC, Cohen J, Moy F, Rosenwaks Z: Endometriosis: A stage by stage analysis—the role of in vitro fertilization. Fertil Steril 1995;64:392–398 Wardle PG, McLaughlin EA, McDermont A, Mitchell JD, Ray BD, Hall MGR: Endometriosis and ovulatory disorder: Reduced fertilization in vitro compared with tubal and unexplained infertility. Lancet 1985;2:236–239 Geber S, Paraschos T, Atkinson G, Margara R, Winston RM: Results of IVF in patients with endometriosis: The severity of the disease does not affect outcome, or the incidence of miscarriage. Hum Reprod 1995;10:1508–1511 Dicker D, Goldman JA, Feldberg D, Ashkenazi J, Levy T: Transvaginal ultrasonic needle-guided aspiration of endometriotic cysts before ovulation induction for in vitro fertilization. J In Vitro Fert Embryo Transfer 1991;8:286–289 Pagidas K, Falcone T, Hemmings R, Miron P: Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril 1996;65:791–795 Nezhat C, Winder W, Nezhat F: Is endoscopic treatment of endometriosis and endometrioma associated with better results than laparoscopy? Am J Gynecol Health 1988;2:10 Yaron Y, Peyser MR, Samuel D, Amit A, Lessing JB: Infected endometriotic cysts secondary to oocyte aspiration for in-vitro fertilization. Hum Reprod 1994;9:1759–1760 Padilla SL: Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod 1993;8:1282–1293 Koninckx PR, Muyldermans M, Moerman P, Meuleman C, Deprest J, Cornille F: CA-125 concentrations in ovarian “chocolate” cyst fluid can differentiate an endometriotic cyst from a cystic corpus luteum. Hum Reprod 1992;7:1314–1317 Author information Authors and Affiliations Rights and permissions About this article Cite this article Isaacs, J.D., Hines, R.S., Sopelak, V.M. et al. Ovarian Endometriomas Do Not Adversely Affect Pregnancy Success Following Treatment With In Vitro Fertilization. J Assist Reprod Genet 14, 551–553 (1997). https://doi.org/10.1023/A:1022592715006 Issue date: DOI: https://doi.org/10.1023/A:1022592715006

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Ovarian Diseases Pregnancy Outcome Adult Embryo Transfer Endometriosis Estradiol Estradiol Female Fertilization in Vitro Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropins Gonadotropins Humans Menstrual Cycle Oocytes Oocytes Ovarian Diseases

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