Endométriose et fécondation in vitro

In: Physiologie, pathologie et thérapie de la reproduction chez l’humain · 2011 · pp. 331–341 · doi:10.1007/978-2-8178-0061-5_29 · W1911382678
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Despite research, the causes of endometriosis and its link to infertility remain unclear except in severe cases with a mechanical factor.

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This chapter reviews what is known about how endometriosis relates to infertility and how outcomes change in the context of in vitro fertilization, drawing on prior studies that address severe cases with a proposed mechanical factor, as well as ovarian reserve, endometrioma effects, surgical treatment timing, and ovarian stimulation protocols. Across the cited evidence, it synthesizes that neither endometriosis etiology nor its full pathophysiology in infertility has been fully elucidated, beyond certain severe presentations. A major limitation is that the chapter’s conclusions are dependent on heterogeneous data from multiple studies with differing stages and interventions rather than providing new experimental results. Relevance to endometriosis: The paper is centrally focused on endometriosis and specifically discusses endometriosis-associated infertility in relation to IVF outcomes, surgical management of endometriomas, and IVF/ICSI parameters.

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Résumé Malgré de multiples recherches, ni l’étiologie de l’endométriose, ni sa physiopathologie dans l’infertilité n’ont pu être élucidées hormis les cas d’endométriose sévères où existe un facteur mécanique (1–3). Preview Unable to display preview. Download preview PDF. Références Burns WN, Schenken RS (1999) Pathophysiology of endometriosis-associated infertility. Clin Obstet Gynecol 42:586–610 Mahutte NG, Arici A (2002) New advances in the understanding of endometriosis related infertility. J Reprod Immunol 55:73–83 Hock DL, Sharafi K, Dagostino L et al. (2001) Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. J Reprod Med 46:7–10 Garcia-Velasco JA, Mahutte NG, Corona J et al. (2004) Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case-control study. Fertil Steril 81:1194–1197 Shahine LK, Burney RO, Behr B et al. (2009) Embryo quality before and after surgical treatment of endometriosis in infertile patients. J Assist Reprod Genet 26:69–73 Aboulghar MA, Mansour RT, Serour GI et al. (2003) The outcome of in vitro fertilization in advanced endometriosis with previous surgery: a case-controlled study. Am J Obstet Gynecol 188:371–375 Marcoux S, Maheux R, Berube S (1997) Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 337:217–222 Parazzini F (1999) Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod 14:1332–1334 Coccia ME, Rizzello F, Cammilli F et al. (2008) Endometriosis and infertility Surgery and ART: an integrated approach for successful management. Eur J Obstet Gynecol Reprod Biol 138:54–59 Somigliana E, Daguati R, Vercellini P et al. (2009) The use and effectiveness of in vitro fertilization in women with endometriosis: the surgeon’s perspective. Fertil Steril 91:1775–1779 Pagidas K, Falcone T, Hemmings R, Miron P (1996) Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril 65:791–795 Fedele L, Bianchi S, Zanconato G et al. (2006) Laparoscopic excision of recurrent endometriomas: long-term outcome and comparison with primary surgery. Fertil Steril 85:694–699 Cahill DJ, Hull MG (2000) Pituitary-ovarian dysfunction and endometriosis. Hum Reprod Update 6:56–66 Sharma RK, Wang Y, Falcone T et al. (1999) Effect of peritoneal fluid from endometriosis patients on sperm motion characteristics and acrosome reaction. Int J Fertil Womens Med 44:31–37. Toya M, Saito H, Ohta N et al. (2000) Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer. Fertil Steril 73:344–350 Dmowski WP, Pry M, Ding J, Rana N (2002) Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. Fertil Steril 78:750–756 Lodhi S, Abdel Fattah A, Abozaid T et al (2004) Gamete intra-fallopian transfer or intrauterine insemination after controlled ovarian hyperstimulation for treatment of infertility due to endometriosis. Gynecol Endocrinol 19:152–159 Hughes EG (1997) The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis. Hum Reprod 12:1865–1872 Werbrouck E, Spiessens C, Meuleman C, D’Hooghe T (2006) No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination. Fertil Steril 86:566–571 Pouly JL, Canis M, Velemir L et al. (2007) La stérilité par endométriose. J Gynecol Obstet Biol Reprod (Paris) 36:151–161 Simón C, Gutiérrez A, Vidal A et al. (1994) Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 9:725–729 Pellicer A, Oliveira N, Ruiz A et al. (1995) Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction. Hum Reprod Suppl 2:91–97 Yanushpolsky EH, Best CL, Jackson KV et al. (1998) Effects of endometriomas on ooccyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: a prospective, case-controlled study. J Assist Reprod Genet 15:193–197 Kuivasaari P, Hippelainen M, Anttila M, Heinonen S (2005) Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod 20:3130–3135 Witsenbourg Dieben S, Van der Westerlaken L, Verburg H, Naaktgeboren N (2005) Cumulative live birth rates in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril 84:99–107 Falconer H, Sundqvist J, Gemzell-Danielsson K et al. (2009) IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-Müllerian hormone. Reprod Biomed Online 18:582–588 Yazbeck C, Madelenat P, Sifer C et al. (2006) Effect of laparoscopic cystectomy on ovarian response in IVF-ET cycles. Gynecol Obstet Fertil 34:808–812 Bianchi PH, Pereira RM, Zanatta A et al. (2009) Extensive Excision of Deep Infiltrative Endometriosis before In Vitro Fertilization Significantly Improves Pregnancy Rates. J Minim Invasive Gynecol 16:174–180 Bedaiwy MA, Falcone T, Katz E et al. (2008) Association between time from endometriosis surgery and outcome of in vitro fertilization cycles. J Reprod Med 53:161–165 Yap C, Furness S, Farquhar C (2004) Pre and post operative medical therapy for endometriosis surgery. Cochrane Database Syst Rev 3:CD003678 Ma C, Qiao J, Liu P, Chen G (2008) Ovarian suppression treatment prior to in-vitro fertilization and embryo transfer in Chinese women with stage III or IV endometriosis. Int J Gynaecol Obstet 100:167–170 Pabuccu R, Onalan G, Kaya C (2007) GnRH agonist and antagonist protocols for stage I–II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. 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(1997) The impact of endometriosis in couples undergoing intracytoplasmic sperm injection because of male infertility. Hum Reprod 12:2282–2285 Demirol A, Guven S, Baykal C, Gurgan T (2006) Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study. Reprod Biomed Online 12:639–643 Pabuccu R, Onalan G, Goktolga U et al. (2004) Aspiration of ovarian endometriomas before intracytoplasmic sperm injection. Fertil Steril 82:705–711 Wong BC, Gillman NC, Oehninger S et al. (2004) Results of in vitro fertilization in patients with endometriomas: is surgical removal beneficial? Am J Obstet Gynecol 191:597–606 Busacca M, Riparini J, Somigliana E et al. (2006) Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol 195:421–425 Canis M, Pouly JL, Tamburro S et al. (2001) Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3 cm in diameter. Hum Reprod 16:2583–2586 Wyns C, Donnez J (2003) Laser vaporization of ovarian endometriomas: the impact on the response to gonadotrophin stimulation. Gynecol Obstet Fertil 31:337–342 Beretta P, Franchi M, Ghezzi F et al. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. (1998) Fertil Steril 70:1176–1180 Saleh A, Tulandi T (1999) Reoperation after laparoscopic treatment of ovarian endometriomas by excision and by fenestration. Fertil Steril 72:322–324 Kubota T, Ishi K, Takeuchi H. (1997) A study of tuboovarian and ovarian abscesses, with a focus on cases with endometrioma. J Obstet Gynaecol Res 23:421–426 Busacca M, Chiaffarino F, Candiani M et al. (2006) Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis. Am J Obstet Gynecol 195:426–432 D’Hooghe TM, Denys B, Spiessens C et al. (2006) Is the endometriosis recurrence rate increased after ovarian hyperstimulation? Fertil Steril 86:283–290 Sachdev R, Bohrer M, Kemmann E (1997) Superovulation therapy does not cause rapid progression of endometriosis. Fertil Steril: 68(Suppl 1):S23 Author information Authors and Affiliations Rights and permissions Copyright information © 2011 Springer-Verlag France, Paris About this chapter Cite this chapter Pouly, JL. et al. (2011). Endométriose et fécondation in vitro . In: Physiologie, pathologie et thérapie de la reproduction chez l’humain. Springer, Paris. https://doi.org/10.1007/978-2-8178-0061-5_29 Download citation DOI: https://doi.org/10.1007/978-2-8178-0061-5_29 Publisher Name: Springer, Paris Print ISBN: 978-2-8178-0060-8 Online ISBN: 978-2-8178-0061-5 eBook Packages: MedicineMedicine (R0)

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