IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-Müllerian hormone

H Falconer, Falconer H, Henrik Falconer, J Sundqvist, Jonas Sundqvist, Sundqvist J, Kristina Gemzell‐Danielsson, Gemzell-Danielsson K, K Gemzell-Danielsson, von Schoultz B, B von Schoultz, Bo von Schoultz, D'Hooghe TM, T M D'Hooghe, TM D'Hooghe, Gerald M. Fried, Fried G, G Fried
Reproductive biomedicine online · 2009 · vol. 18(4) , pp. 582–588 · doi:10.1016/s1472-6483(10)60138-1 · PMID:19401003 · W2117199981
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This study investigated the relationship between IVF outcomes and levels of tumor necrosis factor and anti-Müllerian hormone in women with endometriosis.

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Abstract

This study reports on anti-Müllerian hormone (AMH) in serum and follicular fluid (FF) in relation to inflammatory parameters in women with and without endometriosis undergoing IVF. Serum and FF samples were obtained from 72 women, with (n = 34) and without (n = 38) endometriosis, undergoing IVF. The concentrations of AMH, FSH, tumour necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF) and several interleukins were analysed. Women with endometriosis had significantly lower AMH in serum and FF (serum: 6.38 versus 12.8 pM; P < 0.01, FF: 14.0 versus 19.6 pM; P < 0.05). TNF was increased in FF (40.0 versus 30.8 pg/ml, P < 0.05) from women with endometriosis and significantly higher concentrations of IL-15 and GM-CSF were detected in FF (both P < 0.05). During IVF, women with endometriosis responded well to FSH but had lower fertilization rates. Women with endometriosis have elevated concentrations of several cytokines in FF. They respond adequately to exogenous FSH but may have impaired oocyte quality, reflected in lower fertilization rates, presumably resulting from an inflammatory process in the ovaries. Further studies are needed to elucidate the role of AMH in predicting ovarian reserve in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Fertilization in Vitro Follicular Fluid Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Cytokines Cytokines Endometriosis Female Fertilization in Vitro Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Follicular Fluid Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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