Non-invasive diagnosis of endometriosis with proteomic technologies

Lewis K. Pannell, Ashley R. Mott, Christopher B. Rizk
In: Human Assisted Reproductive Technology · 2011 · pp. 88–100 · doi:10.1017/cbo9780511734755.010 · W2485931071
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews the benefits and applications of the da Vinci surgical system in various gynecological surgeries, including urogynecology and reproductive medicine, and discusses potential future developments.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This chapter examines non-invasive diagnostic approaches for endometriosis that largely rely on proteomic analyses of proteins found in extracellular body fluids. It describes how secreted and membrane-associated proteins (often post-translationally modified, especially via glycosylation) can be detected in fluids such as blood, endometrial fluid, peritoneal fluid, or follicular fluid, with mass spectrometry (using electrospray ionization or MALDI) and sometimes two-dimensional gel analyses used to differentiate proteomic profiles. A major caveat stated is that proteomic differences are typically analyzed either by image-based selection or mass-spectrometry workflows, implying methodological variability in how differential proteins are identified. Relevance to endometriosis: it is the chapter’s central topic, focusing specifically on non-invasive diagnosis of endometriosis with proteomic technologies.

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Abstract

Robotic surgery is emerging as a viable option for gynecological surgeons in general gynecology, urogynecology, oncology, and reproductive surgery. The ZEUS was the first robotic system utilized in gynecological surgery. It is replaced by the robotic system used currently in gynecological surgery: the da Vinci immersive telerobotic system. The da Vinci surgical system consists of three components: a surgeon's console, a patient-side cart with four interactive arms, and a vision cart. The surgeon experiences several benefits while utilizing the da Vinci surgical system. Urogynecologists have started to adopt the new robotic technology. Three studies have examined short-term outcomes, long-term outcomes, and feasibility of robotic-assisted sacrocolpopexy. There are potential uses of robotic-assisted laparoscopic surgery in the field of reproductive medicine. The ability to perform surgery from a remote location can have a significant impact on patient care and access to care, and should be incorporated into future robotic models.
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Human Assisted Reproductive Technology Buy print or eBook [Opens in a new window] Future Trends in Laboratory and Clinical Practice - Human Assisted Reproductive Technology - Human Assisted Reproductive Technology - Copyright page - Dedication - Contents - Contributors - Preface - Acknowledgments - Chapter 1 Use of robotics in reproductive surgery - Chapter 2 Removal of hydrosalpinges and uterine leiomyoma to improve IVF outcome - Chapter 3 Ovarian endometriomas: - Chapter 4 Impact of uterine cavity abnormalities on IVF and pretreatment cavity evaluation - Chapter 5 Sperm retrieval techniques - Chapter 6 New concepts in ovarian stimulation - Chapter 7 GnRH antagonists in ART - Chapter 8 Pharmacogenetics of ovarian stimulation in the twenty-first century - Chapter 9 Non-invasive diagnosis of endometriosis with proteomic technologies - Chapter 10 Antiangiogenic agents for endometriosis - Chapter 11 New concepts in the management of polycystic ovary syndrome - Chapter 12 Adjuvant therapy to increase implantation rates - Chapter 13 Ovarian hyperstimulation syndrome - Chapter 14 The evidence-based practice of assisted reproduction - Chapter 15 Three-dimensional in vitro ovarian follicle culture - Chapter 16 Artificial gametes - Chapter 17 Current status and future trends of the clinical practice of human oocyte in vitro maturation - Chapter 18 Oocyte and zona imaging - Chapter 19 Granulosa cells and their impact on human ART - Chapter 20 Sperm diagnosis: - Chapter 21 Embryo culture in the twenty-first century - Chapter 22 Morphometric analyses of embryos - Chapter 23 Embryo biopsy: - Chapter 24 Analysis of the embryonic transcriptome - Chapter 25 Analysis of embryo-derived factors as markers of developmental potential and viability - Chapter 26 Proteomics analysis of the endometrium and embryo. Can we improve IVF outcome? - Chapter 27 Analysis of embryo metabolism and the metabolome to identify the most viable embryo within a cohort - Chapter 28 Oocyte and embryo cryopreservation - Index Published online by Cambridge University Press: 16 May 2011 Book contents - Human Assisted Reproductive Technology - Human Assisted Reproductive Technology - Copyright page - Dedication - Contents - Contributors - Preface - Acknowledgments - Chapter 1 Use of robotics in reproductive surgery - Chapter 2 Removal of hydrosalpinges and uterine leiomyoma to improve IVF outcome - Chapter 3 Ovarian endometriomas: - Chapter 4 Impact of uterine cavity abnormalities on IVF and pretreatment cavity evaluation - Chapter 5 Sperm retrieval techniques - Chapter 6 New concepts in ovarian stimulation - Chapter 7 GnRH antagonists in ART - Chapter 8 Pharmacogenetics of ovarian stimulation in the twenty-first century - Chapter 9 Non-invasive diagnosis of endometriosis with proteomic technologies - Chapter 10 Antiangiogenic agents for endometriosis - Chapter 11 New concepts in the management of polycystic ovary syndrome - Chapter 12 Adjuvant therapy to increase implantation rates - Chapter 13 Ovarian hyperstimulation syndrome - Chapter 14 The evidence-based practice of assisted reproduction - Chapter 15 Three-dimensional in vitro ovarian follicle culture - Chapter 16 Artificial gametes - Chapter 17 Current status and future trends of the clinical practice of human oocyte in vitro maturation - Chapter 18 Oocyte and zona imaging - Chapter 19 Granulosa cells and their impact on human ART - Chapter 20 Sperm diagnosis: - Chapter 21 Embryo culture in the twenty-first century - Chapter 22 Morphometric analyses of embryos - Chapter 23 Embryo biopsy: - Chapter 24 Analysis of the embryonic transcriptome - Chapter 25 Analysis of embryo-derived factors as markers of developmental potential and viability - Chapter 26 Proteomics analysis of the endometrium and embryo. Can we improve IVF outcome? - Chapter 27 Analysis of embryo metabolism and the metabolome to identify the most viable embryo within a cohort - Chapter 28 Oocyte and embryo cryopreservation - Index This chapter focuses on the non-invasive approaches which largely concentrate on proteomics analyses. Proteins are generated from the genome with signal sequences that direct them to the cell membrane or are secreted in the extracellular environment. Secreted proteins are often post-translationally modified, in particular by glycosylation. These proteins are then released into the interstitial environment where they may enter body fluids such as the blood system and, in the case of endometriosis, be detected in endometrial, peritoneal, or follicular fluids. In most proteomic approaches, mass spectrometry (MS) plays a part in the analyses. Electrospray ionization (ESI) is the most common method for sample introduction into the MS. Matrix assisted laser desorption ionization (MALDI) is also be used as an alternative to ESI. Two-dimensional gel analyses have traditionally been used for the differential analysis of proteomes and differences may be observed and selected visually or using image analysis of scanned gels. - Type - Chapter - Information - Human Assisted Reproductive TechnologyFuture Trends in Laboratory and Clinical Practice, pp. 88 - 100Publisher: Cambridge University PressPrint publication year: 2011 Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future. To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service. - Non-invasive diagnosis of endometriosis with proteomic technologies - - Book: Human Assisted Reproductive Technology - Online publication: 16 May 2011 To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox. - Non-invasive diagnosis of endometriosis with proteomic technologies - - Book: Human Assisted Reproductive Technology - Online publication: 16 May 2011 To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive. - Non-invasive diagnosis of endometriosis with proteomic technologies - - Book: Human Assisted Reproductive Technology - Online publication: 16 May 2011

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endometriosis

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