Non-invasive diagnosis of endometriosis with proteomic technologies

Lewis K. Pannell, Ashley R. Mott, Christopher B. Rizk
In: Human Assisted Reproductive Technology · 2011 · pp. 88–100 · doi:10.1017/cbo9780511734755.010 · W2485931071
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews the benefits and applications of the da Vinci surgical system in various gynecological surgeries, including urogynecology and reproductive medicine, and discusses potential future developments.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This chapter examines non-invasive diagnostic approaches for endometriosis that largely rely on proteomic analyses of proteins found in extracellular body fluids. It describes how secreted and membrane-associated proteins (often post-translationally modified, especially via glycosylation) can be detected in fluids such as blood, endometrial fluid, peritoneal fluid, or follicular fluid, with mass spectrometry (using electrospray ionization or MALDI) and sometimes two-dimensional gel analyses used to differentiate proteomic profiles. A major caveat stated is that proteomic differences are typically analyzed either by image-based selection or mass-spectrometry workflows, implying methodological variability in how differential proteins are identified. Relevance to endometriosis: it is the chapter’s central topic, focusing specifically on non-invasive diagnosis of endometriosis with proteomic technologies.

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Abstract

Robotic surgery is emerging as a viable option for gynecological surgeons in general gynecology, urogynecology, oncology, and reproductive surgery. The ZEUS was the first robotic system utilized in gynecological surgery. It is replaced by the robotic system used currently in gynecological surgery: the da Vinci immersive telerobotic system. The da Vinci surgical system consists of three components: a surgeon's console, a patient-side cart with four interactive arms, and a vision cart. The surgeon experiences several benefits while utilizing the da Vinci surgical system. Urogynecologists have started to adopt the new robotic technology. Three studies have examined short-term outcomes, long-term outcomes, and feasibility of robotic-assisted sacrocolpopexy. There are potential uses of robotic-assisted laparoscopic surgery in the field of reproductive medicine. The ability to perform surgery from a remote location can have a significant impact on patient care and access to care, and should be incorporated into future robotic models.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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