Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers

Sajal Gupta; S. Gupta; Gupta S; A Agarwal; Ashok Agarwal; Agarwal A; Sekhon L; L. Sekhon; Natalie Krajcir; Krajcir N; N Krajcir; Marcello Cocuzza; Cocuzza M; M Cocuzza; Falcone T; T. Falcone; Tommaso Falcone

Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers

Sajal Gupta, S. Gupta, Gupta S, A Agarwal, Ashok Agarwal, Agarwal A, Sekhon L, L. Sekhon, Natalie Krajcir, Krajcir N, N Krajcir, Marcello Cocuzza, Cocuzza M, M Cocuzza, Falcone T, T. Falcone, Tommaso Falcone

Minerva ginecologica · 2006 · vol. 58(6) , pp. 527–51 · PMID:17108882 · W2103340581

Review OA: closed CC0 ⤵ 53 in-corpus citations

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This review summarizes potential serum and peritoneal biomarkers, including cytokines and growth factors, for the non-surgical diagnosis and monitoring of endometriosis, proposing a combined biomarker model for improved accuracy.

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Abstract

Endometriosis is an ambiguous disease and its exact pathogenesis still remains elusive to clinicians and scientists. Local and systemic aberrations in immune response are associated with endometriosis. This article reviews the literature regarding various immunological factors such as cytokines, growth factors, adhesion molecules and angiogenic factors involved in the etiopathogenesis of this disease. Our review summarizes the literature regarding biomarkers, which may be reliable nonsurgical tools used in the diagnosis of endometriosis. Superior biomarkers characterized by high sensitivity, specificity and predictive value can help in the early detection and monitoring of disease progression as well as its response to therapeutic treatments critical for its management. A combination predictive model utilizing multiple biomarkers rather then individual markers alone is proposed to improve the diagnostic performance for identifying women with a high likelihood of having endometriosis. Immunomodulators and angiogenic factor blockers have a potential for endometriosis treatment and also to alleviate the pain or infertility associated with the disease. Potential new therapeutic agents include modulators, such as cytokine receptor blockers and angiogenic receptor blockers, presently used for treating endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Ascitic Fluid Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers Biomarkers Biomarkers Cytokines Cytokines Cytokines Endometriosis Endometriosis Female Female Hormones Hormones Hormones Humans

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References (71)

Cited by (50)

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[1] Activity of eosinophils and immunoglobulin E concentration in the peritoneal fluid of women with endometriosis via openalex

[2] Altered expression of interleukin-18 in the peritoneal fluid of women with endometriosis via openalex

[3] Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues via openalex

[4] CA 125 in benign gynecological conditions via openalex

[5] Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis via openalex

[6] Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis via openalex

[7] Concentration of soluble intercellular adhesion molecule-1 in serum samples from patients with endometriosis collected during the luteal phase of the menstrual cycle via openalex

[8] Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis via openalex

[9] Concentrations of interleukin (IL)-1alpha, IL-1 soluble receptor type II (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra) in the peritoneal fluid and serum of infertile women with endometriosis via openalex

[10] Constitutive or induced elevated levels of L-carnitine correlate with the cytokine and cellular profile of endometriosis via openalex

[11] Cyclic changes of peritoneal fluid parameters in normal and infertile patients via openalex

[12] Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis via openalex

[13] Decreased levels of interleukin-18 in peritoneal fluid but not in serum of patients with endometriosis via openalex

[14] Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets via openalex

[15] Effect of endometriosis on white blood cell subpopulations in peripheral blood and peritoneal fluid of baboons via openalex

[16] Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder via openalex

[17] Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis via openalex

[18] Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis via openalex

[19] Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis via openalex

[20] Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosis via openalex

[21] Expression of interleukin-8 receptors in endometriosis via openalex

[22] Expression of mannose-binding lectin in the peritoneal fluid of women with and without endometriosis via openalex

[23] Fibroblast growth factor (FGF), intracellular adhesion molecule (sICAM-1) level in serum and follicular fluid of infertile women with polycystic ovarian syndrome, endometriosis and tubal damage, and their effect on ICSI outcome via openalex

[24] Fractalkine in the peritoneal fluid of women with endometriosis via openalex

[25] Genetic polymorphism in the fibrinolytic system and endometriosis via openalex

[26] High concentrations of the CA-125, CA 19-9 and CA 15-3 in the peritoneal fluid between patients with and without endometriosis via openalex

[27] IL-1 beta, TNF-alpha, and IL-2 in peritoneal fluid and macrophage-conditioned media of women with endometriosis via openalex

[28] Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? via openalex

[29] Increased activation of pelvic macrophages in infertile women with mild endometriosis via openalex

[30] Increased concentration of vascular endothelial growth factor in the follicular fluid of patients with endometriosis does not affect the outcome of in vitro fertilization-embryo transfer via openalex

[31] Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis via openalex

[32] Increased concentrations of soluble tumour necrosis factor receptor (sTNFR) I and II in peritoneal fluid from women with endometriosis via openalex

[33] Increased ENA-78 in the follicular fluid of patients with endometriosis via openalex

[34] Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis via openalex

[35] Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion via openalex

[36] Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis via openalex

[37] Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and -3 in the follicular fluid of infertile patients with endometriosis via openalex

[38] Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis via openalex

[39] Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis via openalex

[40] Investigation of glutathione concentrations in peritoneal fluid from women with and without endometriosis via openalex

[41] Marked elevation of macrophage migration inhibitory factor in the peritoneal fluid of women with endometriosis via openalex

[42] Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis via openalex

[43] Measurement of serum and peritoneal fluid LH concentrations as a diagnostic tool for human endometriosis via openalex

[44] PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis via openalex

[45] Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis via openalex

[46] Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder via openalex

[47] Peritoneal fluid concentrations of interleukin-8 in patients with endometriosis depend on the severity of the disorder and are higher in the luteal phase via openalex

[48] Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis via openalex

[49] Peritoneal fluid cytokines and sICAM-1 in minimal endometriosis: search for discriminating factors between infertility and/or endometriosis via openalex

[50] Peritoneal fluid leptin concentration in infertile patients via openalex

[51] Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients via openalex

[52] Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial via openalex

[53] Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study via openalex

[54] Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis via openalex

[55] Soluble intercellular adhesion molecule 1 in the peritoneal fluid of patients with endometriosis correlates with the extension of peritoneal implants via openalex

[56] The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis via openalex

[57] The peritoneal environment in endometriosis via openalex

[58] The peritoneal fluid concentration of leptin is increased in women with peritoneal but not ovarian endometriosis via openalex

[59] Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis via openalex

[60] Tumour necrosis factor-alpha blockers: potential limitations in the management of advanced endometriosis? A case report via openalex

[61] Women with endometriosis have increased levels of placental growth factor in the peritoneal fluid compared with women with cystadenomas via openalex

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