CA 125 in Benign Gynecological Conditions

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AI-generated summary by gemini-2.5-flash-lite, 2026-06-07

CA 125 levels can be elevated in various benign gynecological conditions, indicating it is a non-specific marker for peritoneal issues rather than solely ovarian malignancies.

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Abstract

The tumor marker CA 125 was initially thought to be specific for ovarian malignancies. Subsequently it was found to be raised in a variety of benign conditions, including pregnancy, pelvic inflammatory disease, tuberculosis and cirrhosis of the liver. With respect to gynecological tumors, CA 125 may be elevated in benign ovarian cysts, tubo-ovarian abscess, endometriosis, hyperstimulation syndrome, ectopic pregnancy and fibroids. These results demonstrate that CA 125 is a marker of non-specific peritoneal conditions.

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Condition tags

endometriosis

MeSH descriptors

CA-125 Antigen Genital Diseases, Female Genital Diseases, Female Ovarian Neoplasms Biomarkers, Tumor Biomarkers, Tumor CA-125 Antigen Endometriosis Endometriosis Female Genital Diseases, Female Humans Menstruation Menstruation Ovarian Neoplasms Ovarian Neoplasms Pregnancy Pregnancy, Ectopic Pregnancy, Ectopic Pregnancy, Ectopic

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References (48)

Cited by (18)

Source provenance

europepmc
last seen: 2026-08-23T06:15:12.370321+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:29.640636+00:00
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License: CC0 · commercial use OK