Serum CA 125 measurements in the diagnosis of endometriosis recurrence.

Fedele L, Luigi Fedele, L Fedele, Arcaini L, L Arcaini, Luisa Arcaini, Vercellini P, Paolo Vercellini, P Vercellini, Stefano Bianchi, Bianchi S, S Bianchi, G Candiani, G B Candiani, Candiani GB
Obstetrics and gynecology · 1988 · vol. 72(1) , pp. 19–22 · PMID:2967943 · W2405821679
article OA: closed CC0 ⤵ 21 in-corpus citations
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Serum CA 125 levels were significantly higher in women with stages III and IV endometriosis recurrence than in those with less severe disease or no recurrence, showing 100% specificity but low sensitivity.

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Abstract

Seventy-one women underwent follow-up laparoscopy for persistent infertility six to 24 months after conservative treatment of endometriosis. The disease was staged according to the revised American Fertility Society classification of 1985. The serum CA 125 concentration was also measured in each patient to evaluate its efficacy in the diagnosis of endometriosis recurrence. The patients with stages I and II endometriosis had serum CA 125 levels not significantly higher than in the patients with negative findings, whereas those with stages III and IV endometriosis presented significantly higher levels (P less than .005 and P less than .001, respectively) than the disease-free women. The sensitivity of serum CA 125 measurements in the diagnosis of endometriosis recurrence was 14.8%, the specificity was 100%, and the predictive values of normal (less than 35 U/mL) and elevated levels were 27 and 100%, respectively. In some cases, serum CA 125 measurements may be used instead of follow-up laparoscopy, or to indicate when laparoscopy should be performed or postponed.

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Condition tags

endometriosisinfertility

MeSH descriptors

Antigens, Neoplasm Endometriosis Neoplasm Recurrence, Local Pelvic Neoplasms Adult Antigens, Neoplasm Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Evaluation Studies as Topic Female Follow-Up Studies Humans Laparoscopy Neoplasm Recurrence, Local Neoplasm Recurrence, Local Neoplasm Staging Pelvic Neoplasms Pelvic Neoplasms Radioimmunoassay

Citation neighborhood

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Cited by (21)

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