Biochemische Aspekte der Endometriose

In: Gynäkologie und Geburtshilfe 1992 · 1993 · pp. 577–584 · doi:10.1007/978-3-642-77857-5_215 · W2031037663
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Endometriosis is a common gynecological condition with increasing diagnoses due to improved diagnostics.

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This chapter discusses biochemical aspects of endometriosis, noting that it is one of the most common benign gynecologic conditions and that improved diagnostics have led to increasingly frequent diagnoses, with a previously estimated prevalence of about 6–8%. It surveys a body of literature across topics such as serum and peritoneal fluid biomarkers (including CA-125), altered hormone and luteal function, and immunologic/autoreactive phenomena involving antibodies, lymphocyte subsets, and pelvic macrophage activity, alongside mediators like cytokines and prostanoids. A major caveat is that the excerpt provides summary-level statements without detailed methodology or quantified outcomes, limiting the reader’s ability to assess specific effect sizes or study quality from the chapter text alone. This paper is centrally about endometriosis — it reviews biochemical mechanisms and biomarker/immunologic findings relevant to the condition.

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Zusammenfassung Die Endometriose ist eine der häufigsten benignen gynäkologischen Erkrankungen. Verschiedene Autoren vermuten eine Prävalenz in der weiblichen Gesamtbevölkerung von 6-8%. Aufgrund der stark verbesserten diagnostischen Möglichkeiten wird die Diagnose „Endometriose“ zunehmend häufiger gestellt. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others Literatur Badawy, S.Z.A., Cuenca, V., Freliech, B.S., Stefanu, C.: Endometrial antibodies in serum and peritoneal fluid of infertile patients with and without endometriosis Fertil Steril 53, 930–932, 1990 Barbieri, R.L., Niloff, J.M., Bast, R.C., Schaetzel, E., Kistner, R.W., Knapp, R.C.: Elevated serum concentrations of CA-125 in patients with advanced endometriosis Fertil Steril 45, 630–634, 1986 Braun, D.R, Gebel, H., Rotman, C., Rana, N., Dmowski, W.P: The development of cytotoxitity in peritoneal macrophages from women with endometriosis Fertil Steril 57,1203–1210, 1992 Cheesman, K.L., Cheesman, S.D., Chatterton, R.T., Cohen, M.: Alterations in progesterone metabolism and luteal function in infertil women with endometriosis Fertil Steril 40, 590–595, 1983 Cirkel, U., Ochs, H., Latussek, B., Schneider, H.P.G: Aussagekraft der Tumormarker CA-125, CA-19–9, CA-15–3 und CEA bei Endometriose Geb Fra 51, 626–631, 1991 Coddington, C.C., Oehninger, S., Cunningham, D.S, Hansen, K., Sueldo, C.E., Hodgen, G.D.: Peritoneal fluid from patients with endometriosis decreases sperm binding to the zona pellucida in the hemizona assay: a preliminary report Fertil steril 57, 783–786, 1992 Dawood, M.Y., Khan-Dawood, F.S., Ramos, J.: Plasma and peritoneal fluid levels of CA-125 in women with endometriosis Am. J. Obstet. Gynecol. 159, 1526–1531, 1988 Dmowski, W.P., Rao, R., Scommegna, A.: The luteinized unruptured follicle Syndrom and endometriosis Fertil Steril 33, 30–34, 1980 Dmowski, W.P., Steele, R.W.; Baker, G.F.: Deficient cellular immunity in endometriosis Am. J. Obstet. Gynecol. 14, 377–383, 1981 Drake, T.S., O’Brien, W.F., Ramwell, P.W., Metz, S.A.: Peritoneal fluid thromboxane B2 and 6-keto.pristaglandin Fla in endometriosis Am. J. Obstet. Gynecol. 140, 401–404, 1981 El-Roeiy, A., Dmowski, W.P., Gleicher, N., Radwanska, E., Harlow, L., Binor, Z., Tummon, I., Rawlings, R.G.: Danazol but not gonadopriphin-relesing hormone agonists suppresses auto- antibodies in endometriosis Fertil Steril 50, 864–871, 1988 Fakih, H., Baggett, B., Holtz, G., Tsang, K.Y., Lee, J.C., Williamson, H.O.: Interleukin-1: a possible role in the infertility associated with endometriosis Fert Steril 47, 213–217, 1987 Fedele, L., Arcaini, L., Vercellini, P., Bianchi, S., Candiani, G.B.: Serum CA-125 mesuarements in the dignosis of endometriosis recurrence Obstet Gynecol 72, 19–22, 1988 Ferriani, R.A., Jones, D.S.C., Prentice, A., Thomas, E.J., Smith, S.K.: Immunohistochemical localization of acidic and basic fibroplast growth factors in normal human endometrium and endometriosis 3rd world congress on endometriosis 1992 Gleicher, N., Dmowski, W.P., Siwgel, I., Liu, T.L., Friberg, J., Radwanska, E., Toder, V.: Lymphocyte subsets in endometriosis Obstet Gynecol 63, 463–466, 1984 Gleicher, N., El-Roeiy, A., Confino, E., Friberg, J.: Is endometriosis an autoimmune disease? Obstet Cynecol 70, 115–122, 1987 Grunfeld, L, Sandler, B., Fox, J., Kaplan, P., Navot, D.: Luteal phase deficiency after copletely normal follicular and periovulatory phases Fert Steril 52, 919–923, 1989 Halme, J., Becker, S., Hammond, M.G., Raj, H.M.G., Raj, S.: Increased activation of pelvic macrophages in infertile women with mild endometriosis Am.J. Obstet. Gynecol. 145, 333–337, 1989 Hargrove, J.T., Abraham, G.K.: Abnormal luteal function in endometriosis Fert Steril 34, 302, 1980 Hill, J.A., Faris, H.M., Schiff, I, Anderson, D.J.: Characterization of leucocyte subpopulations in the peritoneal fluid of women with endometriosis Fert Steril 50, 216–222, 1988 Kamecia, T., Nagai, S., Yoshino, K., Iijama, Y., Obi, Y., Yamasaki, M.: Interferon-γ secreted from ascitis cells in infertility patients with endometriosis 3rd world congress on endometriosis 1992 Kauppila, A., Telimaa, S., Rooberg, I. et al. Placebo-controlled study on serum concentrations of CA 125 before ans after treatment of endometriosis with danazol or high-dose medroxy- progesterone acetate alone or after surgery Fert Steril 49, 37–41, 1988 Mahmood, T.A., Templeton, A.: Folliculogenesis and ovulation in infertile women with mild endometriosis Hum Reprod. 6, 227–231, 1991 Mathur, S., Peress, M.R., Williamson, H.O. et al.: Autoimmunity to endometrium im women with endometriosis Clin. Exp. Immunol. 50, 259, 1982 Mathur, S., Chihal, HJ., Homm, R.J., Garza, D.E., Rust, P.F., Williamson, H.O.: Endometrial antigens involved in the autoimmunity of endometriosis Fert Steril 50, 860–863, 1988 Meek, S.C., Hodge, D.D., Misich, J.R.: Autoimmunity in infertile patients with endometriosis Am. J. Obsteet. Gynecol. 158, 1365–1369, 1988 Mellor, S.J., Thomas, E.J.: The actions of estradiol and epidermal growth factor in isolated cultures of endometriotic stromal cells 3rd world congress on endometriosis 1992 Muscato, J.J., Wilson, E.A., Weinberg, J.E.: Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis Am. J. Obstet. Gynecol. 144, 503–510, 1982 Muse, K., Wilson, E.A., Jawad, M.J.: Prolactin hyperstimulation in response to THR in patients with endometriosis Meetind of the Society for Gynecologic Investigation, Dallas, Texas, March 1982 Olive, D.L., Haney, A.E, Weinberg, J.B.: The nature of the intraperitoneal exsudate associated with infertility: peritoneal fluid and seum lysozyme activity Fert Steril 48, 802–806, 1987 Olive, D.L. Montoya, I., Riehl, R.M., Schenken, R.S.: Macrophage-conditioned media enchance endometrial stromal cell proliferation in vitro Am. J. Obstet. Gynecol. 164, 953–958, 1991 Oosterlynck, D.J., Cornillie, F.J, Waer, M., Vandeputte, M., Koninckx, P.R.: Women with endometriosis show a defect in natural killer a activity resulting in a decreased cytotoxicity to autologues endometrium Fert Steril 56,45–51, 1991 Rock, J.H., Dubin, H.N., Ghodgaonkar, R.B., Bergquuist, C.A., Erozan, Y.S, Kimball, A.W.: Cul-de-sac fluid in women with endometriosis: fluid volume and Prostanoid concentration during the priliferative phase of the cycle-days 8–12 Fert Steril 37, 747–750, 1982 Schenken, M.R., Asch, R., William, R.F., Hodgen, C.D.: Etiology of infertility in monkeys with endometriosis: Luteinizez unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneuos abortion Fertil Steril 41, 122–130, 1984 Soules, M.R., Malinak, L.R.: Bury, R., Poindexter. A.: Endometriosis and anovulation: acoexisting problem in the infertil female Am.J. Obstet. Gynecol. 125,412–417, 1976 Steele, R.W., Dmowski, W.P., Marmer, D.: Immunologie aspects of human endometriosis Am. J. Reprod. Immunol. 6, 33–36, 1984 Steinleitner, A., Lambert, H., Lauredo, I.: Heterologous transplantation of activated murine peritoneal macrophages inhibits gamete interaction in vivo: a paradigm for endometriosis- associated subfertility Fert Steril 54, 725–729, 1990 Surrey, E.S., Halme, J.: Effect of plateled-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis? Fert Steril 56, 672–679, 1991 Switchenko, A.C., Kauffman, R.S., Becker, M.: Are there antiendometrial entibodies in sera of women with endometriosis? Fert Steril 56, 235–241, 1991 Takahashi, K., Musa, A.A., Nagata, H., Kitao, M.: Serum CA-125 and 17b-estradiol in patients with external endometriosis on danazol Gynecol. Obstet. Invest. 29, 301–304, 1990 Takahashi, K., Nagata, H., Musa, A.A., Shibukawa, T., Yamasaki, H., Kitao, M.: Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis Fert Steril 54, 360–362, 1990 Takemura et al. Matrix Metalloproteinase-III-activities in the ascitis of endometriosis patients 3rd world congress on endometriosis, 1992 Taylor, P.V., Maloney, M.D., Campbell, J.M., Skerrow, S.M., Nip, M., Parmar, R., Tate, G.: Autoreactivity in women with endometriosis Br. J. Obstet. Gynecol. 98, 680–684, 1991 Vernon, M.S., Beard, J.S., Graves, K., Wison, E.A.: Classification of endometriotic implants by morphologic appearance and capacity to synthesize Prostaglandin F Fert Steril 46, 801–806, 1986 Vigano, P., Vercellini, P., DiBlasio, A.M., Colombo, A., Candiani, G.B., Vignali, M.: Deficient antiendometrium lymphocyte-mediated cytotoxicity in patients with endometriosis Fert Steril 56, 894–899,1991 Weed, J.C., Arquenbourg, P.C.: Endometriosis: Can it produce an autoimmune response resulting in infertility? Clin. Obstet. Cynecol. 23, 885–893, 1980 Wild, R.A., Hirisave, V., Bianco, A., Podczaski, E.M., Demers, L.M.: Endometrial antibodies versus CA-125 for the detection of endometriosis Fert Steril 55,90–94, 1991 Ylokorkla, O., Viinikka, C.: Proataglandins in endometriosis Acta. Obstet. Scand. Suppl. 113, 105–107, 1983 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1993 Springer-Verlag Berlin Heidelberg About this paper Cite this paper Runnebaum, B., Kohl, C., Kiesel, L. (1993). Biochemische Aspekte der Endometriose. In: Krebs, D., Berg, D. (eds) Gynäkologie und Geburtshilfe 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77857-5_215 Download citation DOI: https://doi.org/10.1007/978-3-642-77857-5_215 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-77858-2 Online ISBN: 978-3-642-77857-5 eBook Packages: Springer Book Archive

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