Alterations in progesterone metabolism and luteal function in infertile women with endometriosis

Cheesman KL, Kerry L. Cheesman, K L Cheesman, Sara Day Cheesman, Cheesman SD, S D Cheesman, Chatterton RT Jr, Robert T. Chatterton, R T Chatterton, Cohen MR, M R Cohen, Melvin R. Cohen
Fertility and Sterility · 1983 · vol. 40(5) , pp. 590–595 · doi:10.1016/s0015-0282(16)47414-5 · PMID:6226540 · W2415111970
article OA: closed CC0 ⤵ 41 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated how changes in progesterone metabolism and luteal function affect infertility in women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum progesterone (P). PN and BBT rose at midcycle in women with endometriosis, as expected, indicating secretion of some P at that time. However, PGD, the major endpoint of P metabolism, was delayed in its excretion. Endometrial biopsies were similarly delayed (out of phase) in women with endometriosis, and a significantly higher incidence of follicular luteinization was seen. It appears that while P secretion begins at midcycle, the bulk of P secretion is delayed, perhaps because of the process of follicular luteinization, and that a shortened functional luteal phase thus exists in women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Corpus Luteum Endometriosis Infertility, Female Progesterone Adult Biopsy Body Temperature Corpus Luteum Endometriosis Endometriosis Female Humans Infertility, Female Laparoscopy Luteinizing Hormone Luteinizing Hormone Pregnanediol Pregnanediol Pregnanolone Pregnanolone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (41)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:09:55.985569+00:00
License: CC0 · commercial use OK