Alterations in progesterone metabolism and luteal function in infertile women with endometriosis

Cheesman KL, Kerry L. Cheesman, K L Cheesman, Sara Day Cheesman, Cheesman SD, S D Cheesman, Chatterton RT Jr, Robert T. Chatterton, R T Chatterton, Cohen Mr, M R Cohen, Melvin R. Cohen
Fertility and sterility · 1983 · vol. 40(5) , pp. 590–595 · doi:10.1016/s0015-0282(16)47414-5 · PMID:6226540 · W2415111970
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This study investigated how changes in progesterone metabolism and luteal function affect infertility in women diagnosed with endometriosis.

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Abstract

The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum progesterone (P). PN and BBT rose at midcycle in women with endometriosis, as expected, indicating secretion of some P at that time. However, PGD, the major endpoint of P metabolism, was delayed in its excretion. Endometrial biopsies were similarly delayed (out of phase) in women with endometriosis, and a significantly higher incidence of follicular luteinization was seen. It appears that while P secretion begins at midcycle, the bulk of P secretion is delayed, perhaps because of the process of follicular luteinization, and that a shortened functional luteal phase thus exists in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Corpus Luteum Endometriosis Infertility, Female Progesterone Adult Adult Biopsy Biopsy Body Temperature Body Temperature Corpus Luteum Corpus Luteum Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (39)

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