Pathophysiology of Infertility in Endometriosis

Bruce A. Lessey, Steven L. Young
In: Endometriosis · 2011 · pp. 240–254 · doi:10.1002/9781444398519.ch23 · W1540423184
other OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review explores the pathophysiology of infertility in endometriosis, highlighting potential progesterone resistance and estrogen hypersensitivity in the endometrium, and suggesting impaired endometrial receptivity as a leading mechanism.

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Abstract

Endometriosis is a disease affecting up to 10% of reproductive-aged women, but contributing to the majority of cases of pelvic pain and infertility. The association between infertility and mild endometriosis remains controversial, despite multiple lines of evidence. Treatment of endometriosis appears to be associated with improvement in cycle fecundity. The pathophysiology of endometriosis and infertility is not well understood, but is likely linked to the origins, maintenance and recurrence of the disease. Recognition of the biochemical alterations in eutopic endometrium of women with endometriosis suggests an underlying resistance to the actions of progesterone and an exaggerated responsiveness to estrogen. While the theories regarding the mechanisms of infertility associated with endometriosis are protean, a defect in endometrial receptivity leading to delayed fertility or pregnancy loss is the one that is most accepted, supported by available evidence. Identification of the key factors in the serum, peritoneal fluid or endometrium that are linked to infertility may provide diagnostic biomarkers for future studies of this enigmatic disease.

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endometriosisinfertility

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last seen: 2026-06-10T17:14:06.276822+00:00
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