Emerging role of genomics in endometriosis research

Robert N. Taylor, Taylor RN, Lundeen SG, Scott G. Lundeen, Giudice LC, Linda C. Giudice
Fertility and sterility · 2002 · vol. 78(4) , pp. 694–698 · doi:10.1016/s0015-0282(02)03325-3 · PMID:12372442 · W1964325356
review OA: bronze CC0 ⤵ 54 in-corpus citations
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This review explores the increasing importance of genomics in understanding the genetic basis and potential therapeutic targets for endometriosis.

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Abstract

ObjectiveRapidly evolving methods in genomics and proteomics research already are changing the nature of biomedical investigation. In this report we briefly review some of the seminal technological advances that inspired the genomics revolution and describe their application in the field of endometriosis research.DesignReview of different techniques successfully applied to endometriosis research.SettingCollaborative investigation in academic and pharmaceutical industry laboratories.Patient(s)Biopsies were obtained from consenting ovulatory women on no medications, with or without laparoscopically proven endometriosis.Result(s)Genomics techniques have confirmed gene products shown to be abnormally expressed in endometriotic tissues by prior studies. In addition, identification of novel transcripts not previously appreciated in this condition were discovered. Examples of dysregulated genes in endometriosis include glycodelin, complement, early growth response-1 and transducer of erbB-1.Conclusion(s)Global gene profiling studies are poised to revolutionize the diagnosis and treatment of endometriosis and other human diseases.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genomics Research Biopsy Cytogenetic Analysis Endometriosis Endometriosis Female Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Proteome Proteome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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License: CC0 · commercial use OK