c-myc protooncogene polypeptide expression in endometriosis
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This study investigated c-myc protooncogene polypeptide expression in endometriosis and reported its findings.
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Abstract
The c-myc protooncogene and its polypeptide product are important regulators of cell proliferation and differentiation, and ovarian steroids are believed to stimulate growth of various uterine cell types through altered expression of the c-myc gene. To determine whether c-myc expression may also be involved in the growth and development of endometriosis, we assessed c-myc expression in eutopic and ectopic endometrial tissue obtained from women undergoing surgery for endometriosis. Immunocytochemistry using a monoclonal antibody to the c-myc protein demonstrated positive staining of glandular and stromal cell nuclei, and cytoplasmic staining of glandular but not stromal cells in both eutopic and ectopic endometrium. These findings suggest that c-myc expression may be an important regulator of cell proliferation in endometriotic tissue.
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Cited by (32)
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- Targeting c-MYC: a potential non-hormonal therapeutic approach for endometriosis treatment 2023
- RPLP1 Is Up-Regulated in Human Adenomyosis and Endometrial Adenocarcinoma Epithelial Cells and Is Essential for Cell Survival and Migration In Vitro 2023
- How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence 2019
- 60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival <i>in vitro</i> 2019
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- Correlation Between the Clinical Parameters and Tissue Phenotype in Patients Affected by Deep-Infiltrating Endometriosis 2016
- Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery 2015
- Molecular mechanisms underlying endometriosis pathogenesis revealed by bioinformatics analysis of microarray data 2015
- Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis 2015
- Severe teenage acne and risk of endometriosis 2014
- MicroRNAs and the pathogenesis of endometriosis 2012
- The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis 2012
- Endometriosis: Disease Classification and Behavior 2011
- The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis? 2009
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- Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression 2005
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