Histochemical localization of specific estrogen and progesterone binding in human endometrium and endometriotic tissue

Agneta Bergqvist, A Bergqvist, Bergqvist A, Kjell Carlström, Carlström K, K Carlström, Jeppsson S, S Jeppsson, Sten Jeppsson, Ljungberg O, O Ljungberg, Otto Ljungberg
Acta obstetricia et gynecologica Scandinavica. Supplement · 1984 · vol. 63(S123) , pp. 15–16 · doi:10.3109/00016348409156973 · PMID:6594006 · W2074773663
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This histochemical method detected specific estrogen and progesterone binding sites in both epithelial and stromal components of human endometrium and endometriotic tissue, with similar patterns observed in corresponding lesions.

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Abstract

A histochemical method for the detection of steroid-binding sites in very small tissue specimens was evaluated. Competitive binding experiments proved the method to be sufficiently specific. When applied to endometrium and endometriotic tissue obtained simultaneously from the same patient, a distinct binding was found both in the epithelial structures and in the stroma. The binding pattern in endometriotic glands resembled that in the endometrium. The study seems thus to support the conclusion that endometriotic lesions contain specific binding sites for estrogen and progesterone and that their distribution seems to be similar to that found in the endometrium from the same patient.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Estrogens Progesterone Adult Binding, Competitive Endometriosis Endometrium Estrogens Female Histocytochemistry Humans Middle Aged Progesterone

Citation neighborhood

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