Tissue Factors Influencing Growth and Maintenance of Endometriosisa

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AI-generated summary by claude@2026-06, 2026-06-10

Endometrial and endometriotic implants express estrogen, progesterone, and epidermal growth factor receptors, with Danazol and GnRHa reducing epidermal growth factor receptor staining.

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Abstract

The unpredictable response of endometriosis to steroids and its recurrence after therapy, led us to hypothesize a possible further control of this pathology by factors other than steroids. The presence of estrogen, progesterone and epidermal growth factor receptors (ER, PR, EGFr) was evaluated using immunohistochemistry before and after therapy with Danazol or a gonadotropin-releasing hormone analogue (GnRHa), Buserelin. EGFr, ER and PR were present in 100% of endometrial specimens, and in 71%, 29% and 49% of endometriotic implants, respectively. Danazol and GnRHa reduced immunohistochemical staining for EGFr antisera in the endometrial and endometriotic specimens. About 21% of endometriosis were EGFr positive and ER negative, suggesting a potential role of epidermal growth factor in growth and maintenance of endometrial ectopia.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis ErbB Receptors Receptors, Estrogen Receptors, Progesterone Adult Buserelin Buserelin Danazol Danazol Dinoprostone Dinoprostone Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium ErbB Receptors ErbB Receptors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (36)

SciLite annotations

chemicals 7
steroid steroid estrogen progesterone danazol buserelin danazol

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
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