BASIC RESEARCH IN ENDOMETRIOSIS

Kathy L. Sharpe-Timms, K L Sharpe-Timms, Sharpe-Timms KL
Obstetrics and gynecology clinics of North America · 1997 · vol. 24(2) , pp. 269–290 · doi:10.1016/s0889-8545(05)70304-1 · PMID:9163767 · W2038548751
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews basic research findings related to endometriosis, covering topics such as its pathophysiology, molecular mechanisms, and potential therapeutic targets.

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Abstract

A more thorough understanding of the mechanisms associated with the cause and pathophysiology of endometriosis may help in the development of new diagnostic and therapeutic methods for the management of endometriosis. Research has begun to enhance our understanding of endometriosis by demonstrating the differences and similarites between eutopic and ectopic endometrium, and by characterizing the peritoneal environment. Animal models have been developed and validated to conduct studies that are ethically impossible in women. Recently, cell culture models, using purified populations of cells from endometriotic lesions, have provided an appropriate in vitro endometriosis model to study the language by which cells communicate; to evaluate the biochemical effects of steroids, growth factors, pharmacological agents and immunomodulatory agents on the cells; and to study the effects of endometriosis on reproduction.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Animals Ascitic Fluid Ascitic Fluid CA-125 Antigen CA-125 Antigen Cells, Cultured Colony-Stimulating Factors Colony-Stimulating Factors Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Membrane Glycoproteins Membrane Glycoproteins Research

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (39)

Source provenance

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