Protein, progesterone, and protease inhibitors in uterine and peritoneal fluids of women with endometriosis

Fazleabas AT, A T Fazleabas, Asgerally T Fazleabas, Firyal S. Khan‐Dawood, F S Khan-Dawood, Khan-Dawood FS, M. Yusoff Dawood, Dawood MY, M Y Dawood
Fertility and sterility · 1987 · vol. 47(2) , pp. 218–224 · doi:10.1016/s0015-0282(16)49994-2 · PMID:3817170 · W2474186577
article OA: closed CC0 ⤵ 13 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study measured levels of proteins, progesterone, and protease inhibitors in uterine and peritoneal fluids of women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study was undertaken to determine whether women with endometriosis have altered protein, progesterone (P), and protease inhibitor concentrations in their uterine fluid and peritoneal fluid (PF) compared with controls at different phases of the menstrual cycle. Uterine flushings (UFs), PF, and blood were obtained during the follicular and luteal phases of the cycle from 29 normal women and 16 women who were diagnosed as having endometriosis. Protein content in UF did not change significantly throughout the cycle in either group. However, PF protein in patients with endometriosis was significantly (P less than 0.05) higher than in controls during the luteal phase. Total UF P was significantly (P less than 0.05) reduced in women with endometriosis during the late luteal phase. During the early luteal phase, trypsin inhibitory activity in UF from normal women was significantly (P less than 0.05) higher than at any other phase of the cycle, whereas inhibitory activity in UF from patients with endometriosis remained relatively constant. Patients with endometriosis had significantly (P less than 0.05) higher total activity in PF during the early luteal phase than did controls. These results indicate that women suffering from endometriosis have significantly lower levels of P and less protease inhibitor within their uterine cavity during the luteal phase of the cycle, and significantly higher concentrations of protein and protease inhibitor in PF during the luteal phase.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Body Fluids Endometriosis Ovarian Neoplasms Progesterone Protease Inhibitors Proteins Uterus Ascitic Fluid Body Fluids Endometriosis Female Humans Infertility, Female Infertility, Female Menstrual Cycle Ovarian Neoplasms Progesterone Protease Inhibitors Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (13)

Source provenance

europepmc
last seen: 2026-08-29T06:12:09.280863+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:09:30.565292+00:00
License: CC0 · commercial use OK