Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain
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This study investigated peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain.
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Abstract
Peritoneal fluid obtained at laparoscopy from 49 women was measured for its content of prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), 6-keto-prostaglandin F1 alpha (6-KF), and thromboxane B2 (TxB2) by specific radioimmunoassays. In normal women (n = 10), the concentrations of prostaglandins in peritoneal fluid were (mean +/- SE): PGE2 = 0.79 +/- 0.26, PGF2 alpha = 0.60 +/- 0.18, 6-KF = 0.48 +/- 0.19, and TxB2 = 0.23 +/- 0.09 ng/ml; in women with endometriosis (n = 16): PGE2 = 1.43 +/- 0.72, PGF2 alpha = 1.52 +/- 0.59, 6-KF = 3.32 +/- 0.71, and TxB2 = 1.14 +/- 0.69 ng/ml; in women with chronic pelvic inflammatory disease and/or obstructed tubes (n = 19): PGE2 = 1.94 +/- 1.04, PGF2 alpha = 1.20 +/- 0.61, 6-KF = 1.55 +/- 0.40, and TxB2 = 0.64 +/- 0.24 ng/ml; in women with pelvic pain without any visible pathologic condition (n = 4): PGE2 = 1.11 +/- 0.66, PGF2 alpha = 0.73 +/- 0.55, 6-KF = 1.35 +/- 0.35, and TxB2 = 0.39 +/- 0.17. The mean volumes of peritoneal fluid recovered were 10 to 16 ml and were not significantly different between the groups. Except for a significantly elevated concentration of 6-KF in the peritoneal fluid of women with endometriosis compared to normal women (p = less than 0.02), the prostaglandins measured did not differ significantly between the groups of women studied. The possible significance of elevated 6-KF in the peritoneal fluid of women with endometriosis is discussed.
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- Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages 2020
- Chronic pelvic pain 2016
- Endometriosis 2016
- Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model 2015
- Abnormal Expression of Prostaglandins E2 and F2<i>α</i>Receptors and Transporters in Patients with Endometriosis 2015
- C-Jun NH2-Terminal Kinase and p38 Inhibition Suppresses Prostaglandin E2-Stimulated Aromatase and Estrogen Receptor Levels in Human Endometriosis 2015
- Chronic Pelvic Pain in Endometriosis: An Overview 2013
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- Pelvic pain in women with ovarian endometrioma is mostly associated with coexisting peritoneal lesions 2012
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- Immune interactions in endometriosis 2011
- Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis 2011
- Prostaglandin E <sub>2</sub> : the master of endometriosis? 2010
- Prostaglandin E <sub>2</sub> : the master of endometriosis? 2010
- Endometriosis 2007
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- Suppression of Matrix Metalloproteinase-9 by Prostaglandin E2 in Peritoneal Macrophage Is Associated with Severity of Endometriosis 2005
- Suppression of Matrix Metalloproteinase-9 by Prostaglandin E2 in Peritoneal Macrophage Is Associated with Severity of Endometriosis 2005
- Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium 2004
- Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis 2002
- Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells 2001
- Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model 2001
- Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells 2001
- Peritoneal fluid interleukin-6 in women with chronic pelvic pain 2000
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Endometriotic disease: the role of peritoneal fluid 1998
- Endometriosis and Pelvic Pain 1998
- Abuse-Related Posttraumatic Stress Disorder and Alterations of the Hypothalamic-Pituitary-Adrenal Axis in Women With Chronic Pelvic Pain 1998
- Endometriosis-associated infertility 1997
- PATHOPHYSIOLOGY 1997
- PGE2 and PGF2α release by human peritoneal macrophages in endometriosis 1996
- Review of Peritoneal Factors that Affect Fertility in Patients With Mild Endometriosis 1996
- Treatment of Infertility Associated With Endometriosis 1995
- Pathogenesis of Infertility in Endometriosis 1995
- Pathogenesis of Pelvic Pain in Endometriosis 1995
- Human Peritoneal Macrophage and T Lymphocyte Populations in Mild and Severe Endometriosis 1995
- A mid-luteal phase comparison of V76 peritoneal fluid volume and its content of PGF2α and PGE2 in women with minimal stage endometriosis and a normal pelvis 1994
- 8 Endometriosis-associated infertility 1993
- Changing concepts of medical treatment of endometriosis 1993
- Nonsteroidal antiinflammatory drugs and reproduction 1993
- In vitro lymphocyte activity in women with endometriosis—an altered immune response? 1992
- Prostaglandins in Dysmenorrhoea and Endometriosis 1992
- Relationships between pelvic pain and prostaglandin levels in plasma and peritoneal fluid collected from women after sterilization 1992
- IL6 and acute phase plasma proteins in peritoneal fluid of women with endometriosis 1992
- The endometrium and endometriosis 1991
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