The relevance of the peritoneal fluid in endometriosis-associated infertility

Mulayim N, Naciye Mülayim, N Mulayim, A Arici, Arici A, Aydın Arıcı
Human Reproduction · 1999 · vol. 14(suppl 2) , pp. 67–76 · doi:10.1093/humrep/14.suppl_2.67 · PMID:10690802 · W2096801073
review OA: bronze CC0 ⤵ 17 in-corpus citations
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This review discusses how endometriosis-associated infertility may be influenced by immunological factors within the peritoneal fluid, which surrounds endometriotic lesions and is the site of early reproductive events.

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Abstract

Endometriosis, one of the most prevalent gynaecological disorders, may affect fertility. Extensive research has been done in an attempt to understand the pathogenesis of endometriosis and its association with reproductive failure. It has been suggested that the disease affects almost any step of reproduction, but data are mostly controversial so it is difficult to draw clear conclusions from studies that have been done so far. Not only is peritoneal fluid in close proximity to endometriotic lesions, but it is also the environment in which early reproductive events take place. Studies on the peritoneal fluid in endometriosis have provided significant data towards an understanding of this disease. Immunological factors play a key role in determining the occurrence of endometriosis as well as its heterogenous symptoms. Since data also indicate that there are immunological differences between infertile and fertile women with endometriosis, recent studies have been designed to take these differences into consideration. This review will discuss the mechanisms by which endometriosis may affect fertility, and an emphasis will be placed on the relevance of the peritoneal fluid.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Infertility, Female Infertility, Female Ascitic Fluid Embryo Implantation Embryonic and Fetal Development Endometriosis Female Fertilization Humans Infertility, Female Ovulation Reproduction

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (17)

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License: CC0 · commercial use OK