Histochemical demonstration of estrogen and progesterone binding in endometriotic tissue and in uterine endometrium: A comparative study.
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This histochemical study found that epithelial cells in both endometriotic and uterine endometrial tissues exhibit specific binding sites for estrogen and progesterone.
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Abstract
Estrogen and progesterone binding to endometriotic and endometrial tissue was studied histochemically using estradiol and progesterone fluorochrome derivatives (E2-bovine serum albumin-fluorescein isothiocyanate and progesterone-bovine serum albumin-tetramethylrhodamine isothiocyanate). Thirty endometriotic samples from 21 women were studied, together with endometrial specimens obtained simultaneously from 14 of the women. In 77% of the endometriotic samples binding of the estrogen conjugate was indicated by specific fluorescence in more than half of the epithelial cell population, and in 20% in less than half. The corresponding figures for the progesterone conjugate binding were 75 and 18%, respectively. Blocking studies indicated a reasonable degree of ligand specificity. In endometrial tissue the corresponding figures were 64 and 29%, respectively, for binding of the estrogen conjugate and 54 and 38%, respectively, for binding of the progesterone conjugate. In 7 of 13 cases where evaluable samples of both tissues had been obtained, the relative proportion of fluorescent cells, with either reagent, was similar in the two tissue types. Our results suggest that the cytoplasm of epithelial cells in endometriotic tissue and in uterine endometrium contains specific binding sites for both estrogen and progesterone. The binding pattern of the two conjugates in endometriotic tissue was unrelated to the menstrual phase.
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Cited by (14)
- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
- 17βE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFκB-dependent pathway 2009
- A Modified Baboon Model for Endometriosis 2002
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Endometriosis and Infertility: New Concepts 1999
- Angiogenesis and Macrophage Activation in Endometriosis 1997
- Endometriosis and Infertility 1997
- Combined use of a long-acting gonadotropin-releasing hormone agonist and low-dose danazol in advanced stage endometriosis 1996
- Expression of estrogen and progesterone receptors and their mRNAs in ovarian endometriosis 1996
- Diseases of the Peritoneum 1994
- 4 Markers for endometriosis 1993
- Steroid receptors in endometriosis 1991
- Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy 1989
- Histology and ultrastructure of human endometriotic tissues treated with dydrogesterone (Duphaston) 1987
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- europepmc
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- openalex
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- pubmed
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