Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy

Lessey BA, Bruce A. Lessey, B A Lessey, Metzger DA, D A Metzger, Déborah Metzger, Haney AF, A F Haney, K S McCarty, McCarty KS Jr, Kenneth S. McCarty
Fertility and Sterility · 1989 · vol. 51(3) , pp. 409–415 · doi:10.1016/s0015-0282(16)60545-9 · PMID:2646155 · W2411047141
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This study immunohistochemically analyzed estrogen and progesterone receptor expression in endometriosis and normal endometrium across the menstrual cycle, also assessing the impact of medical therapy.

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Abstract

Estrogen receptors (ER) and progesterone receptors (PgR) in 19 endometriotic implants from 16 normally cycling and hormonally treated women were measured using immunohistochemical techniques and compared with 34 samples of normal intrauterine endometrium. Endometriotic implants contained specific ER and PgR in both glandular epithelium and stroma. In contrast to intrauterine endometrium, receptor content among implants was noted to be more heterogeneous, and did not undergo predictable changes in response to endogenous hormones. In the endometriotic implants of patients treated with hormonal therapy, there were significant decreases in ER and PgR in both the glands and stroma relative to untreated patients. These data imply that endometriosis is unpredictable in its response to the cyclic hormonal milieu in terms of ER and PgR, but retains the ability to respond to hormonal suppression over a prolonged interval.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Pelvic Neoplasms Receptors, Estrogen Receptors, Progesterone Adult Antibodies, Monoclonal Endometriosis Endometriosis Endometrium Female Hormones Hormones Humans Immunoenzyme Techniques Menstrual Cycle Middle Aged Pelvic Neoplasms Pelvic Neoplasms Receptors, Estrogen

Citation neighborhood

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References (29)

Cited by (50)

Source provenance

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