Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17β-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism
article
OA: closed
CC0
⤵ 40 in-corpus citations
Limited metadata. Only one source feed has indexed
this record so far — no abstract, full text, or open-access copy is
available through Endo Lab. The
publisher's page (linked below)
is the canonical location for the actual content. If you have institutional
access, use "Find at my library".
AI-generated summary
Endometrial stromal cells from women with endometriosis lack the ability to produce paracrine factors that induce epithelial 17β-HSD2 gene expression and Sp1 binding, leading to impaired estradiol metabolism.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (34)
- Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis via openalex
- Aromatase expression in endometriosis. via openalex
- Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex
- Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex
- Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex
- Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. via openalex
- Mechanisms of excessive estrogen formation in endometriosis via openalex
- Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
- Progesterone Induction of 17β-Hydroxysteroid Dehydrogenase Type 2 during the Secretory Phase Occurs in the Endometrium of Estrogen-Dependent Benign Diseases But Not in Normal Endometrium via openalex
- Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
- Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex
- Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex
- W2109525253 via openalex
- W2150921740 via openalex
- W2160579552 via openalex
- W2167644938 via openalex
- W2325144754 via openalex
- W2606253041 via openalex
- W6656356435 via openalex
- W6658221620 via openalex
- W6664125244 via openalex
- W1525342509 via openalex
- W6736802628 via openalex
- W1529983368 via openalex
- W1977344247 via openalex
- W1977482986 via openalex
- W2010311608 via openalex
- W2034055061 via openalex
- W2047249984 via openalex
- W2053321628 via openalex
- W2054594056 via openalex
- W2059793937 via openalex
- W2063767041 via openalex
- W2095215902 via openalex
Cited by (40)
- Hormonal imbalance-mediated immune inflammation in endometrial decidualization disorder 2025
- Horizons in Endometriosis: Proceedings of the Montreux Reproductive Summit, 14-15 July 2023 2024
- A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses 2024
- Effect of Oral Contraceptive Use in Relation to Fertile Years on the Risk of Endometriosis in Women with Primary Infertility: A Ten-Year Single-Centre Retrospective Analysis 2024
- Inflammatory Changes after Medical Suppression of Suspected Endometriosis for Implantation Failure: Preliminary Results 2024
- Pattern-recognition receptors in endometriosis: A narrative review 2023
- Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis 2020
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
- Endometriosis 2019
- Endometriosis 2019
- Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data 2018
- The Endometriotic Tumor Microenvironment in Ovarian Cancer 2018
- Physiological and pathological implications of retinoid action in the endometrium 2018
- Correlation of Progesterone Receptor B in Endometrial Tissue of Menstrual Blood in Patients with and without Endometriosis 2018
- Estrogen Biosynthesis and Its Regulation in Endometriosis 2017
- Retinoid Metabolism in Endometriosis 2017
- Altered retinoid signaling compromises decidualization in human endometriotic stromal cells 2017
- Estrogen Biosynthesis and Its Regulation in Endometriosis 2017
- Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis 2016
- Pathophysiology and Immune Dysfunction in Endometriosis 2015
- Epithelial-to-mesenchymal transition in the development of adenomyosis 2015
- Oestrogen‐induced angiogenesis promotes adenomyosis by activating the <scp>S</scp>lug‐<scp>VEGF</scp> axis in endometrial epithelial cells 2014
- Potential role of aromatase inhibitors in the treatment of endometriosis 2014
- Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer 2013
- Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis 2013
- A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis 2012
- Aromatase inhibitors for the treatment of endometriosis 2012
- Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action 2011
- Is There A Relationship between Polycystic Ovary Syndrome and Endometriosis? 2011
- Signaling Pathways in Endometriosis (Eutopic/Ectopic) 2011
- Estrogen biosynthesis and signaling in endometriosis 2011
- 17β-Hydroxysteroid Dehydrogenase-2 Deficiency and Progesterone Resistance in Endometriosis 2010
- Progestins for the Treatment of Endometriosis: An Update: 2010
- Progestins for the Treatment of Endometriosis: An Update 2010
- Altered Retinoid Uptake and Action Contributes to Cell Survival in Endometriosis 2010
- Molecular profiling of human endometrium and endometriosis 2010
- Deregulation of LOXL1 and HTRA1 Gene Expression in Endometriosis 2010
- Estrogen metabolism and action in endometriosis 2009
- The non-human primate model of endometriosis: research and implications for fecundity 2009
- Estrogen metabolizing enzymes in endometrium and endometriosis 2007
Source provenance
- europepmc
- last seen: 2026-06-30T06:11:02.404677+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:15:00.519696+00:00
- unpaywall
- last seen: 2026-06-30T06:26:37.652333+00:00
License: CC0
· commercial use OK